Milano didn't participate in Wednesday's practice due to a knee issue, Chris Brown of the Bills' official site reports.
Head coach Sean McDermott referred to Milano as day-to-day with the knee injury, which the linebacker presumably picked up during the Bills' Week 13 win over the Patriots last Thursday. Milano will have two more opportunities to get back on the practice field before the Bills decide whether he carries an injury designation into Sunday's contest against the Jets. Through 11 appearances on the season, Milano has tallied 67 tackles, six pass breakups, two interceptions, one fumble recovery and one touchdown.