The incident happened around 8:35 a.m. Sunday, Nov. 27 in Hempstead.
A 43-year-old man operating a 2016 Ford Van and the 61-year-old woman driving a 2014 Hyundai were involved in the crash at the intersection of Washington Street and Lent Avenue, Nassau County Police said.
The woman sustained serious injuries and was transported to a nearby hospital for treatment, police said.
She is currently in critical condition, according to police, who have not yet released her identity.
The investigation is ongoing.
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