Benford suffered an oblique injury in Thursday's 28-25 win over the Lions, Chris Brown of the Bills' official site reports.
Benford played 32 snaps while tallying four tackles prior to exiting the game. There was no official diagnosis provided, though coach Sean McDermott noted that Benford is week-to-week. That puts his status for Thursday's Week 13 matchup against the Patriots in serious jeopardy.