Developing a smartwatch to detect unwitnessed out-of-hospital cardiac arrests

In hemophilia A cases, the body either partially or completely lacks the blood coagulation factor VIII (FVIII), or the factor is formed incorrectly. Patients usually receive FVIII that comes from donor blood or is produced using genetic engineering. However, about one third of those treated for severe hemophilia A develop antibodies (inhibitors) against FVIII. Researchers at the Paul-Ehrlich-Institut have found that complement proteins from the immune system strongly influence the reactions of T cells (immune cells) to FVIII and can be involved in inhibitor formation. Haematologica reported on the results of their work in its online edition on February 2, 2023.

Many patients don't receive much rehabilitation therapy following a stroke, despite strong evidence that higher amounts can reduce long-term disability, according to a new UCLA-led study that tracked over 500 patients across 28 acute care hospitals in their first year following a stroke. The new research, published in the journal...

A single-dose of the antiviral drug peginterferon lambda reduced by half the risk of hospitalization or a visit to the Emergency Department due to COVID-19, according to a study published today in the New England Journal of Medicine. The multi-center phase 3 TOGETHER clinical trial—designed to test a new therapy...

A new method to reduce the progression of diabetic kidney disease, affecting 40% of people with diabetes, has been discovered by scientists. The University of Bristol-led study published today in JCI Insight, could help the 4.8 million people in the UK with diabetes who are four times more likely to need either dialysis or a kidney transplant.

For people living with epilepsy who have tried various epilepsy treatments to control their seizures with little success, there is another option. It's a surgery called resection of an epileptic focus, or resective surgery—where surgeons remove or disconnect the area in the brain that is no longer properly functioning and is generating seizures. Dr. Jonathon Parker, a Mayo Clinic neurosurgeon, explains how this surgery works.

Removing the $5 prescription charge for people in areas of high socioeconomic deprivation reduces the number of hospital admissions and the length of stays, a new study shows. Researchers, led by Professor Pauline Norris of the University of Otago's Va'a o Tautai—Center for Pacific Health, are recommending the charges be dropped for people with high health needs and low incomes or be scrapped entirely.

Commonly used systems to identify sepsis fail to detect many cases in patients initially admitted to hospital for severe traumatic injuries, researchers at the University of Washington School of Medicine in Seattle have found. "The failure of these systems to identify these cases likely mean we are underappreciating the importance...

An alcohol brief intervention (BI) in primary care can improve health outcomes for adults with hypertension, according to a study published online Jan. 19 in BMJ Open. Felicia W. Chi, M.P.H., from Kaiser Permanente Northern California in Oakland, and colleagues examined the correlations between alcohol BI in primary care and outcomes among 72,929 adults with hypertension and 19,642 adults with type 2 diabetes (T2D) who screened positive for unhealthy alcohol use. The study was conducted in a health care system that implemented alcohol screening, BI, and referral to treatment.

Targeting calcium signaling in neurons represents a promising therapeutic approach for treating a rare form of schizophrenia, according to a Northwestern Medicine study published in Biological Psychiatry. "This is the first time that human neurons are made and characterized from schizophrenia patients with the 16p11.2 duplication, one of the most...

With nature's events more frequently edging into natural disasters caused by climate change, patients with chronic kidney disease who require regular dialysis increasingly struggle to stay connected to this lifesaving service. The deepening threat drove Professor Amir Sapkota, chair of the Department of Epidemiology and Biostatistics at the University of...

UConn Assistant Professor of Immunology Zhichao Fan specializes in the molecular mechanics of inflammation, specifically the mechanism that activates the adhesion of white blood cells or leukocytes in inflammation associated with heart attacks and the repair of blocked coronary arteries. One type of white blood cell—neutrophils—is of particular interest to Fan and at the heart of groundbreaking research he is leading into the novel use of a leukocyte-inhibiting drug to reduce tissue damage in patients undergoing coronary catheterization.

When it comes to bunions, millions of Americans are painfully familiar with the signs: Swelling, redness, a telltale bulge on the side of the big toe. Corns and calluses where other toes rub together. And pain. Lots and lots of pain. Fortunately, when surgery is needed, it's usually a success....