Cardinals vs. Pirates prediction, betting odds for MLB on Wednesday

Jack Suwinski

Pittsburgh Pirates' Jack Suwinski hits an RBI single during the third inning of the team's baseball game against the St. Louis Cardinals, Tuesday, Oct. 4, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)AP

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The Pittsburgh Pirates square off with the St. Louis Cardinals in MLB at PNC Park on Wednesday. First pitch is at 4:05 p.m. ET.

The Pirates will send Johan Oviedo (4-3, 3.12 ERA) to the mound, pitting him against Matthew Liberatore (2-1, 5.46 ERA) for the Cardinals.

This betting preview for Cardinals vs. Pirates, which features our best bet of the game, is courtesy of Caesars Sportsbook and powered by Dimers.

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Cardinals vs. Pirates 2022

Game details

  • When: Wednesday, October 5, 2022
  • Time: 4:05 p.m. ET
  • Where: PNC Park

Betting odds

  • Run line: Pirates -1.5 (+158), Cardinals +1.5 (-180)
  • Moneyline: Pirates -135, Cardinals +115
  • Total: Over/Under 7.5 (-110/-110)

Odds and lines are best available at time of publishing and subject to change.

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Cardinals vs. Pirates betting preview

Based on advanced data and machine learning, Dimers has simulated Wednesday’s Cardinals vs. Pirates game 10,000 times.

Dimers’ famous predictive analytics model, better known as DimersBOT, gives the Cardinals a 52% chance of beating the Pirates.

Furthermore, according to DimersBOT, the Cardinals (+1.5) are a 68% chance of covering the run line. The Over/Under total of 7.5 runs is a 60% chance of going Over.

As always, predictions and probabilities are correct at time of publishing and subject to change.

Cardinals vs. Pirates best bet

Our best bet for Cardinals vs. Pirates in MLB on Wednesday is Over 7.5 runs (-110).

Click ➡️ here ⬅️ to place a wager with Caesars Sportsbook.

Our betting tips are based on detailed simulations and wagering intelligence to help you make more informed decisions.

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Wednesday’s matchup between the Cardinals and Pirates in MLB at PNC Park is scheduled to start at 4:05 p.m. ET.

The oldest professional sports league in the world is Major League Baseball. MLB has 30 teams, including the Cardinals and Pirates.

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