Inactives:
- RB Tyrion Davis-Price (ankle)
- WR Danny Gray (hip)
- DT Javon Kinlaw (knee)
- TE Tyler Kroft (knee)
- DB Tarvarius Moore (hamstring)
- T Trent Williams (ankle)
- OL Nick Zakelj
Kinlaw tried to test his knee ahead of the game but is unable to go. Defensive lineman Arik Armstead (foot) is active after missing last week's game against the Denver Broncos.
Ahead of the game, the 49ers signed wide receiver Willie Snead from the practice squad to the active roster. The team also elevated running back Tevin Coleman and wide receiver Malik Turner from the practice squad to the active roster.
San Francisco officially placed linebacker Azeez Al-Shaair (knee) on the injured reserve list. He will have to miss at least four games.