Trent Alexander-Arnold is not included in England's matchday squad as Gareth Southgate's side prepare to face Germany at Wembley on Monday night.
Harry Maguire, however, is expected to keep his place at the heart of the England defence with his most regular partner, John Stones, due to return alongside him.
Sky Sports News has been told Southgate will continue with three centre-backs, though it's unclear at this stage whether it will be Eric Dier or Kyle Walker paired with Maguire and Stones.
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England's five-game winless run is their longest since 2014 and Friday's meek 1-0 loss at absentee-hit Italy saw them relegated from the Nations League's top tier with a game to spare.
Monday's clash with Germany is a dead rubber as a result, but it remains key for England in terms of improving the mood and rebuilding confidence in their final match before the World Cup begins.
In-form Brentford forward Ivan Toney, who has scored five goals and recorded two assists in the Premier League this season, has been included in the matchday squad for the first time having missed out against Italy last week.
AC Milan defender Fikayo Tomori, West Ham's Jarrod Bowen and Southampton midfielder James Ward-Prowse also join Alexander-Arnold on the absentee list, while Manchester City's Jack Grealish is suspended.
Monday's game is England's final match before Southgate announces his squad for the November-December World Cup in Qatar, where they will face Iran, United States and Wales in the group stage.
'Maguire impressed Southgate despite shaky start'
Sky Sports News senior reporter Rob Dorsett:
"The England defence was heavily criticised in the aftermath of the 1-0 defeat to Italy on Friday night, but the England boss is understood to have been impressed by the way Maguire settled into the game, after a shaky first 20 minutes, despite not starting a Premier league match for Manchester United in six weeks.
"Southgate is determined to build Maguire's confidence, give him game time, and convince him he's a key part of the England team for the World Cup.
"Stones was suspended for the game in the San Siro, but is in line for an immediate return to the starting XI.
"The reuniting of Maguire and Stones is a sign that Southgate is returning to his most tried and trusted players, as he desperately seeks a morale-boosting win in England's final game before the World Cup.
"Tomori, who some feel is England's most in-form centre back right now, isn't even in the matchday 23, having not featured against Italy either."
England's World Cup Group B fixtures
November 21: Iran (Khalifa International Stadium, Al Rayyan) - kick-off 1pm
November 25: USA (Al Bayt Stadium, Al Khor) - kick-off 7pm
November 29: Wales (Ahmed bin Ali Stadium, Al Rayyan) - kick-off 7pm