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Officials were dispatched to the two-story home in the 3400 block of Village Drive North around 2:30 p.m. after reports of a fire, according to Prince George's County Fire.
Once on the scene, crews found smoke coming from the basement.
Searches of the residence came up negative, however one resident who had self-evacuated was airlifted from the scene with serious life-threatening injuries.
One Prince George's County Fire Department Firefighter was reported injured and has been transported for evaluation, officials said.
The fire has been extinguished and an investigation is ongoing.
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