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Delayed platelet recovery and mortality after allogeneic stem cell transplantation in children

Bone Marrow Transplantation volume 57, pages 1347–1349 (2022)Cite this article

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Thrombocytopenia is a common complication after allogeneic hematopoietic cell transplantation (HCT) with an incidence ranging from 5% to 40% [1]. It is associated with impaired platelet production or increased platelet destruction [1]. Delayed platelet recovery (DPR) after allogeneic HCT using peripheral blood, bone marrow (BM) and umbilical cord grafts was shown to be a predictor of increased transplant-related mortality (TRM) and poor overall survival (OS) in adults [2, 3]. Studies which found an association between DPR and outcomes in adults did not include transplant cell doses in multivariate analysis. Since DPR may be a result of low CD34+ cell doses, we wanted to investigate if DPR was associated with poor outcomes in children when transplant cell doses were included in the analyses.

In this retrospective study, 255 consecutive patients less than 21 years of age with hematological malignancies who underwent a first allogeneic HCT at St. Jude Children’s Research Hospital (St. Jude) with a BM graft between January 2000 through December 2015 (both inclusive) were included. The study was approved by the St. Jude Institutional Review Board.

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Data availability

All data generated or analyzed during this study are included in this published article [and its Supplementary Information files].

References

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Acknowledgements

The authors thank Lina Alloush and Carlton Hughes from the human applications laboratory at St. Jude for assistance in collecting data.

Funding

This work was supported by NCI Cancer Center CORE Support Grant P30 CA 21765 and by ALSAC. JRW was supported by NCI Grant R25C0A23944.

Author information

Authors and Affiliations

  1. Department of Anesthesiology, University of Kentucky College of Medicine, Lexington, KY, USA

    Joseph R. Wells

  2. Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Guolian Kang

  3. Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Ali Y. Suliman, Ying Li, Brandon Triplett & Ashok Srinivasan

  4. Human Applications Laboratory, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Salem Akel

  5. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA

    Brandon Triplett & Ashok Srinivasan

Authors
  1. Joseph R. Wells
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  2. Guolian Kang
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  3. Ali Y. Suliman
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  4. Ying Li
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  5. Salem Akel
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  6. Brandon Triplett
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  7. Ashok Srinivasan
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Contributions

AS designed the study and wrote the manuscript. JRW and AYS collected the data and revised the manuscript. GK and YL performed the statistical analysis and revised the manuscript. SA and BT revised the manuscript and contributed to cell processing (SA) and patient management (BT).

Corresponding author

Correspondence to Ashok Srinivasan.

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The authors declare no competing interests.

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Wells, J.R., Kang, G., Suliman, A.Y. et al. Delayed platelet recovery and mortality after allogeneic stem cell transplantation in children. Bone Marrow Transplant 57, 1347–1349 (2022). https://doi.org/10.1038/s41409-022-01726-2

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