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Quality of life following cord blood versus matched sibling donor transplantation: pre-transplantation psychiatric and socioeconomic factors significantly impact outcomes

Bone Marrow Transplantation volume 57, pages 1344–1346 (2022)Cite this article

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There are limited data comparing quality of life (QOL) of long-term non-relapsed cord blood (CB) stem cell transplant (SCT) survivors to matched related donor (MRD) survivors [1, 2]. We used seven surveys to assess comprehensively QOL in relapse-free patients surviving at least 1 year post transplant.

This study was approved by the Colorado Multiple Institutional Review Board. Patients alive without relapse at least 1 year after SCT were asked to participate in the study and were emailed QOL surveys. Surveys included the Functional Assessment of Cancer Therapy–Bone Marrow Transplant (FACT-BMT), a 37-item assessment that measures QOL post-SCT [3], RAND-36 Short Form Quality of Life Survey (RAND-36), a measure of health-related QOL [4], Patient Health Questionnaire 8 (PHQ-8) (with question from PHQ-9 related to suicidality omitted), a measure that assesses symptoms of major depressive disorder [5], Generalized Anxiety Disorder 7‐Item Scale (GAD-7), a measure of symptoms of generalized anxiety disorder [6], Pittsburgh Sleep Quality Inventory (PSQI), a 21-item measure that assesses sleep quality [7], Impact of Event Scale – Revised (IES-R), a 22-item measure that assesses subjective distress caused by traumatic events [8], and FACIT-F (version 4), a 13-item tool that measures fatigue [9].

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors thank all of the patients and the outstanding team at the Blood Disorders Center at the University of Colorado.

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Authors and Affiliations

  1. Division of Hematology, University of Colorado, Denver, CO, USA

    Benjamin Brewer, Prashant Sharma, Neel Gakhar, Timothy S. Sannes, Tanisha K. Joshi, Rebecca Hunter, Diana Abbott & Jonathan A. Gutman

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  1. Benjamin Brewer
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  2. Prashant Sharma
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  8. Jonathan A. Gutman
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Contributions

BB, PS, NG, DA, and JAG designed research, performed research, analyzed data, and wrote the paper. TSS, TKJ, and RH analyzed data and wrote the paper.

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Correspondence to Jonathan A. Gutman.

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The authors declare no competing interests.

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Brewer, B., Sharma, P., Gakhar, N. et al. Quality of life following cord blood versus matched sibling donor transplantation: pre-transplantation psychiatric and socioeconomic factors significantly impact outcomes. Bone Marrow Transplant 57, 1344–1346 (2022). https://doi.org/10.1038/s41409-022-01721-7

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