Elucidation of the mechanisms that drive tumor resistance to anti-angiogenic therapies is expected to improve treatment options. This report shows that endothelial apelin signaling promotes the migration of distant venous endothelial cells toward the tumor progenitor cell niche to support vessel expansion and sustain a normoxic microenvironment, and that it does so independently of vascular endothelial growth factor A.
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This is a summary of: Bernier-Latmani, J. et al. Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00061-5 (2022).
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Apelin drives endothelial cell migration toward intestinal progenitor cells. Nat Cardiovasc Res 1, 546–547 (2022). https://doi.org/10.1038/s44161-022-00079-9
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DOI: https://doi.org/10.1038/s44161-022-00079-9
