The Saints will visit their former NFC West rival San Francisco 49ers in Week 12 at 3:25 p.m. on November 20 on FOX. New Orleans secured the win at home in the last matchup between these squads in 2020, marking their ninth win in the last 12 matchups between the teams.
New Orleans Saints 4-8
San Francisco 49ers 7-4
The 49ers hold a 48-27-2 edge in the all-time series, but New Orleans took the win the last time these two teams met up in 2020. With the Saints and 49ers NFC West rivals from 1970-2001, San Francisco holds a 48-27-2 edge in the all-time regular season series, but the Saints have captured nine of the last 12. The San Francisco contest will close out New Orleans' 2022 slate against NFC West opponents.
Head Coach: Kyle Shanahan
Quarterback: Jimmy Garoppolo
Key Position Players: TE George Kittle, RB Elijah Mitchell, WR Deebo Samuel, DL Nick Bosa
Head Coach: Dennis Allen
Quarterback: Andy Dalton
Key Position Players: RB Alvin Kamara, WR Chris Olave, S Tyrann Mathieu
