From Bills vs. Rams in the season opener to Joe Burrow vs. Tom Brady in Week 15, these are the NFL's best matchups of 2022

Before we dive into the 272-game excitement that is the 2022 NFL regular-season schedule, here are some of the latest happenings around the league:

• Drew Brees is reportedly done announcing football games for NBC after one season on the job.
• Hall of Famer Jerome Bettis made good on a promise to get his degree from Notre Dame.
• Jarvis Landry is coming home after signing with the New Orleans Saints.
• Former NFL standout Frank Gore won his pro boxing debut with a one-punch knockout.

The schedule for the upcoming NFL season is out and it presents a number of enticing matchups to hype up over the next few months. From Tom Brady and Patrick Mahomes facing off in Tampa, to Dallas Cowboys coach Mike McCarthy returning to Green Bay to face his former team, USA TODAY Sports' Mike Jones has the top 10 matchups for the 2022 season.

Each weekend of the 18-week regular season will have intriguing storylines, and USA TODAY Sports' Parker Gabriel picks out the best game for each week.

NFL schedule release: Notes and analysis

• Schedule release winners and losers: Some teams might be more thankful than others for how their regular-season slates were sequenced.
• Top grudge matches for 2022: From free-agent frenzies to postseason principles, these are the top grudge matches of the 2022 NFL season.
• 8 worst games of 2022 schedule: Everyone knows the marquee matchups that await. But there are several games that even diehards will have a difficult time watching.
• Oddsmakers break down NFL Week 1: Knowing the hearty appetite of football bettors, oddsmakers rapidly unveiled Week 1 point spreads when the NFL released its 2022 season schedule Thursday. 
• Every crazy schedule release video: NFL teams really went all out for this year when releasing their 2022 schedules on social media.
• One make-or-break stretch for each AFC West team: These crucial stretches will determine which team will win the most talked-about division in football. 

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