Fluorescent probe can track cancer drug progress, study shows

An Emory University study published in Molecular Psychiatry shows levodopa, a drug that increases dopamine in the brain, has potential to reverse the effects of inflammation on brain reward circuitry, ultimately improving symptoms of depression. Numerous labs across the world have shown that inflammation causes reduced motivation and anhedonia, a...

A monoclonal antibody treatment was found to be safe, well tolerated, and effective in protecting against malaria in a small group of healthy volunteers who were exposed to malaria in a challenge study, according to new research published in The Lancet Infectious Diseases by researchers at the University of Maryland School of Medicine (UMSOM).

Findings from a Johns Hopkins Children's Center study in animal models show that a U.S. Food and Drug Administration (FDA)-approved antibiotic regimen for multidrug-resistant (MDR) tuberculosis (TB) may not work for TB meningitis. Studies in a small number of people also provide evidence that a new combination of drugs is needed to develop effective treatments for TB meningitis due to MDR strains.

The first comprehensive study of somatic mutations in normal human small intestine has been conducted by researchers at the Wellcome Sanger Institute and their collaborators. The findings revealed that an enzyme named APOBEC1 is likely responsible for two mutational signatures found in many cancers, SBS2 and SBS13, in the small intestine.

Even a simple movement like pushing a button sends ripples of activity throughout networks of neurons spanning across the brain, new University of Oregon research shows. The finding highlights just how complex the human brain is, challenging the simplified textbook picture of distinct brain areas dedicated to specific functions. "It's...

The world's first human-monkey hybrid has been successfully created in a laboratory, according to shocking research from Chinese scientists. This horrifying development occurred in 2021, after a team of researchers from the United States and Spain traveled to China in order to get around regulations that forbade this kind of research in their own nations.

A new study by University of Manchester audiologists has highlighted the difficulties people face with impacted ear wax. The findings are published in the British Journal of General Practice as more and more people face the prospect of ear wax removal services being discontinued at their GP surgeries. However, despite...

As a child, Lynn Aureli didn't know that a particular genetic change contributed to her acute myeloid leukemia (AML)—an alteration that eventually would help explain the cancer's lack of response to chemotherapy. Nor was she aware that her cancer had hijacked the genetic mechanism for maintaining the stem cells that form blood, like those in the bone marrow transplant that saved her life.

Expanding anesthesiology residency programs—even in the absence of federal funding—may help medical institutions save staffing costs and address projected shortages of anesthesia care professionals, suggests a first-of-its-kind study being presented at the American Society of Anesthesiologists' ADVANCE 2023, the Anesthesiology Business Event. In the wake of the COVID-19...

Periodontitis, a gum disease, can lead to a litany of dental issues from bad breath to bleeding and lost teeth. Now, researchers at Hiroshima University have found that it could be connected to even more severe problems elsewhere in the body—the heart. In a study published in JACC: Clinical...

COVID vaccines call our immune systems to action, generating antibodies which fight against any contact we have with the virus. Antibodies help to reduce the effects of an infection or even prevent it altogether. Scientists have estimated that vaccination has averted millions of COVID deaths worldwide. Studies have also shown...

Researchers at the Francis Crick Institute and King's College London have created a tool to predict the effects of different diets on both cancerous cells and healthy cells. Their work could help disentangle the subtle metabolic changes associated with different types of nutrients, and improve our understanding of the link between diet and disease.

Videos appearing to show people experiencing severe side effects after allegedly receiving COVID-19 vaccines are making the rounds on social media as part of a renewed push from anti-vaccine movements to cast doubt on safety. Twitter users have shared videos of people who've claimed to have experienced tremors, seizures, paralysis,...

The world's first international clinical guidelines to help prevent and treat heart complications in children undergoing cancer treatment have been created. The guidelines, published in JACC:Advances, cover cardiovascular disease assessment, screening and follow-up, for pediatric patients receiving cancer treatment with new molecular therapies, immunotherapy, chemotherapy and radiotherapy. The expert consensus,...

Patients with myelofibrosis had clinically significant improvement in disease-related symptoms, including anemia and spleen enlargement, when treated with the targeted therapy momelotinib, according to results from the international Phase III MOMENTUM trial led by researchers at The University of Texas MD Anderson Cancer Center. The findings, published today in The...

Current medical standards for accessing stroke risk perform worse for Black Americans than they do for white Americans, potentially creating a self-perpetuating driver of health inequities. A study, led by Duke Health researchers and appearing online Jan. 24 in the Journal of the American Medical Association (JAMA), evaluated various existing...

The University of York-led study showed that health professionals, working with faith leaders, can deliver effective, low-cost messages on how people can keep their blood pressure on the healthy side. High blood pressure can lead to a range of health conditions such as heart disease, heart attack, and strokes. The...

Glaucoma is one of the world's leading causes of blindness, according to the Centers for Disease Control and Prevention. January is Glaucoma Awareness Month. Half of people with glaucoma don't even know they have it. If you're over 60 or have a family history of glaucoma, your risk is higher.

Many people are experiencing a variety of long COVID-19 symptoms and are relying on some of their own methods to allay those symptoms. Others are in need of additional therapies from their medical care team. Researchers from Germany asked patients experiencing post-COVID symptoms about the therapies they used and found...

A new report has highlighted the consequences of misinformation, including loss of trust in public institutions, delayed action on pressing issues such as climate change, and the financial toll on health care services during the COVID-19 pandemic. The "Fault Lines" report involved a panel of international experts, including leading cognitive...