Exploring the delivery systems of plasmid DNA and messenger RNA for advanced therapies

Tragic events like wars, famines, earthquakes, and accidents create fearful memories in our brain. These memories continue to haunt us even after the actual event has passed. Luckily, researchers from Tokyo University of Science (TUS) have recently been able to understand the hidden biochemical mechanisms involved in the selective suppression of fearful memories, which is called fear extinction. The researchers, who had previously demonstrated fear extinction in mice using the chemically synthesized compound "KNT-127," have now identified the underlying mechanism of this compound's action. Their findings have been published recently in Frontiers in Behavioral Neuroscience.

A study led by experts from NHS Golden Jubilee and the University of Glasgow into the effects of COVID-19 on Scottish patients in Intensive Care Units (ICUs) has confirmed evidence that the virus is associated with impaired function of the right side of the heart. Specialists at NHS Golden Jubilee's...

Across the world, food allergies are on the rise. One of the most important cells in studying this ailment are basophils, which activate inflammation and other responses to allergens such as rashes, and sometimes, anaphylaxis. But basophils are exceedingly rare in a typical vial of blood, comprising 1% or less of all white blood cells. In order to advance the science of food allergies—and to learn more about this elusive cell—engineers and clinicians at Stanford University have focused their attention on a way to isolate basophils.

A new study has found that a simple, one-off treatment was able to prevent long term side effects of cancer radiotherapies. There are about 2 million cancer survivors in the UK, and many of them face premature memory loss and faster occurrence of various diseases resembling premature aging, to which sadly, there is no cure. This is thought to be caused by side effects of toxic cancer chemotherapies and radiotherapies, which aim to treat cancer cells but can also damage normal cells.

A special type of MRI found lung abnormalities in patients who had previously had COVID-19, even those who had not been hospitalized with the illness, according to a new study published in the journal Radiology. "In a collaboration between the University of Oxford and the University of Sheffield, we have...

The pharmaceutical company Pfizer has voluntary recalled a blood pressure medication for the second time in a month. Pfizer is recalling five lots of blood pressure medicine Accupril because of elevated levels of a nitrosamine, Nnitroso-quinapril, the company said in a news release posted Friday on the FDA website. Nitrosamines...

MILLIONS of Brits have been urged to take up a rapid test to see if they have bowel cancer. The Health Secretary has called on men over 60 to make sure they have the life-saving checkups. It couldn't be easier - with a home testing kit on offer, or use...

Walking at a brisk pace for just 75 minutes every week could cut your risk of depression, a new study finds. The World Health Organization recommends everyone should exercise for at least two-and-a-half hours every seven days. But researchers at Cambridge University, England, found adults who got half as much...

Christine Bronstein took at home colon cancer test after seeing blood in her stool. It was positive, but her doctor texted: "You don't have cancer :)"

One in eight people who were hospitalized with COVID-19 between May 2020 and March 2021 were later diagnosed with myocarditis, or heart inflammation, according to major new research into the clinical long-term effects of COVID-19. The largest study of its kind to date was led by the University of Glasgow...

In a follow-up on the 14th Ebola Virus Disease (EVD) outbreak in the Democratic Republic of the Congo (DRC) (HERE and HERE), the World Health Organization (WHO) tweeted today:. Health authorities in #DRC confirmed a 2nd case of #Ebola in Mbandaka on 25 April. The 25-year old woman, now deceased, began experiencing symptoms 12 days earlier. Investigations indicate that as the 1st case patient’s sister-in-law, she was a high-risk contact.

The drug gabapentin, currently prescribed to control seizures and reduce nerve pain, may enhance recovery of movement after a stroke by helping neurons on the undamaged side of the brain take up the signaling work of lost cells, new research in mice suggests. The experiments mimicked ischemic stroke in humans,...

Unmarried heart failure patients appear less confident in managing their condition and more socially limited compared to their married counterparts, according to research presented May 21 at Heart Failure 2022, a scientific congress of the European Society of Cardiology (ESC). These differences may have contributed to the worse long-term survival observed in unmarried patients.

Shielding those vulnerable to COVID-19, while allowing the virus to spread, largely unmitigated, through the rest of the population, would have failed according to a new modeling paper published today in PLOS Global Public Health by University of Bath scientists. Shielding strategies or "focused protection", as advocated for in the...

Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin are widely used to treat pain and inflammation. But even at similar doses, different NSAIDs can have unexpected and unexplained effects on many diseases, including heart disease and cancer. Now, a new Yale-led study has uncovered a previously unknown process by...

Breakthrough COVID-19 cases resulting in infections, hospitalizations and deaths are significantly more likely in cancer and Alzheimer's patients, according to two new studies from researchers at the Case Western Reserve University School of Medicine. People within these diseases are often more susceptible to infection in general, the researchers explained, and...

According to a new study that was presented May 21 at the 24th European Congress of Endocrinology in Milan, Italy, vitamin D food fortification worked better with water and milk than in juice. By measuring the maximum concentration over time, the researchers found bioavailability of vitamin D to be higher in milk and water.

In a study published in Nature on May 16, a research team led by University of Wisconsin–Madison virologist Yoshihiro Kawaoka and colleagues in Japan show that the BA.2 subvariant of omicron is similar to BA.1 in both the severity of illness it causes and in its ability to cause infection.

For patients receiving concurrent chemoradiotherapy for squamous cell carcinoma of the head and neck, higher doses of gabapentin are well tolerated and associated with delayed time to first opioid use for additional pain control during radiotherapy (RT), according to a research letter published online May 18 in JAMA Network Open.

Watching too much TV is associated with increased risk of coronary heart disease regardless of an individual's genetic makeup, say a team of scientists at the Medical Research Council (MRC) Epidemiology Unit, University of Cambridge and the University of Hong Kong. In a study published today in BMC Medicine, the...