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Two-time women's lightweight champ Kayla Harrison, men's welterweight champ Ray Cooper III headline third Professional Fighters League event of 2022 season

The PFL has announced its opening women's lightweight and men's welterweight matchups for the 2022 regular season, and the matchups include some of the company's biggest names.

Two-time women's lightweight champion Kayla Harrison (12-0) will face Russia's Marina Mokhnatkina (6-2) in the PFL 3 main event. In the co-main event, 2021 welterweight champion Ray Cooper III (24-7-1) will meet Magomed Umalatov (11-0).

The PFL 3 event will take place on May 6 at Esports Stadium Arlington in Arlington, Texas, the same venue as PFL 1 (April 20) and PFL 2 (April 28). Those earlier events will feature the promotion's other four weight classes: heavyweight, light heavyweight, lightweight and welterweight.

A two-time Olympic gold medalist in judo, Harrison was not guaranteed to return to the PFL in 2022. She received multiple offers as a free agent in late 2021 and early 2022. Bellator MMA offered Harrison a lucrative deal; however, the PFL had the right to match the offer and opted to do so.

According to ESPN, Harrison is tied as the No. 7 female pound-for-pound fighter.

In addition to the main and co-main, PFL 3 will feature former UFC lightweight champion Anthony Pettis against Myles Price. That bout was originally scheduled for April 20 but was postponed.

PFL events are scheduled to air on ESPN, ESPN Deportes and ESPN+ in 2022. Additional regular-season events are scheduled for June 17, June 24 and July 1.

The full lineup for PFL 3 on May 6 includes:

Kayla Harrison vs. Marina Mokhnatkina, women's lightweight

Ray Cooper III vs. Magomed Umalatov, welterweight

Anthony Pettis vs. Myles Price, lightweight

Rory MacDonald vs. Brett Cooper, welterweight

Magomed Magomedkerimov vs. Joao Zeferino, welterweight

Genah Fabian vs. Julia Budd, women's lightweight

Sadibou Sy vs. Nikolai Aleksakhin, welterweight

Larissa Pacheco vs. Zamzagul Fayzallanova, women's lightweight

Gleison Tibau vs. Jarrah Al Silawi, welterweight

Olena Kolesnyk vs. Abigail Montes, women's lightweight

Vanessa Melo vs. Martina Jindrova, women's lightweight