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A new metabolite, mannogeranylnerol, specifically produced at body temperature by Schizophyllum commune, a causative fungus of human mycosis

The Journal of Antibiotics volume 75, pages 243–246 (2022)Cite this article

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Abstract

Schizophyllum commune is a causative fungus of human mycosis. Its metabolites produced at 27 °C were compared with those produced at 37 °C, to obtain a candidate low-molecular-weight virulence factor related to the pathogenicity of this fungus. We found that S. commune specifically produces two acyclic terpene mannosides at 37 °C. They were identified as nerolidol β-d-mannoside (1) and geranylnerol β-d-mannoside (2) by NMR, MS, and CD analyses. Compound 2, a new compound named mannogeranylnerol, showed weak antibiotic activity that was slightly stronger than that of compound 1.

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Fig. 1
Fig. 2

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Acknowledgements

The authors thank Dr. Karikomi of Utsunomiya University for the measurement of the CD spectra.

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Authors and Affiliations

  1. Department of Biosciences, Teikyo University, 1-1 Toyosatodai, Utsunomiya, 320-8551, Japan

    Shing Yiu Tam, Kenichi Uchida, Hirofumi Enomoto, Senji Takahashi & Shohei Sakuda

  2. Institute of Medical Mycology, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan

    Koichi Makimura

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  1. Shing Yiu Tam
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  2. Kenichi Uchida
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Correspondence to Shohei Sakuda.

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Tam, S.Y., Uchida, K., Enomoto, H. et al. A new metabolite, mannogeranylnerol, specifically produced at body temperature by Schizophyllum commune, a causative fungus of human mycosis. J Antibiot 75, 243–246 (2022). https://doi.org/10.1038/s41429-022-00511-z

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