Scientists demonstrate utility of Bilateral Tumor Model for evaluating anti-cancer T-cell responses

Tragic events like wars, famines, earthquakes, and accidents create fearful memories in our brain. These memories continue to haunt us even after the actual event has passed. Luckily, researchers from Tokyo University of Science (TUS) have recently been able to understand the hidden biochemical mechanisms involved in the selective suppression of fearful memories, which is called fear extinction. The researchers, who had previously demonstrated fear extinction in mice using the chemically synthesized compound "KNT-127," have now identified the underlying mechanism of this compound's action. Their findings have been published recently in Frontiers in Behavioral Neuroscience.

Immunotherapy after surgery helped reduce cancer recurrence in patients with urothelial cancer of the bladder or other sites in the urinary tract that had invaded the muscle and therefore posed a high risk for recurrence, according to clinical trial results presented at the American Urological Association (AUA) annual meeting in May.

Researchers led by King's College London, Karolinska Institute and Erasmus University have identified 10 new genes linked with hearing loss and located the part of the ear affected. The findings, published today in American Journal of Human Genetics, cast doubt on the understanding that age-related hearing impairment originates mainly from...

Small cell lung cancer (SCLC) is a malignant disease associated with a particularly high mortality rate. According to a new multicenter study led by MedUni Vienna and conducted in collaboration with researchers from the Czech Republic, Hungary, Slovenia, Sweden and the United States, SCLC can be divided into several subgroups in terms of clinical behavior. These subtypes respond differently to chemotherapeutics and targeted drugs. This opens up possibilities for personalized treatment for this type of cancer as well.

A second line of defense—the immune system's T cells—may offer protection from COVID-19 even when vaccine-induced antibodies no longer can, according to new research out of the University of Wisconsin School of Veterinary Medicine. The researchers discovered that a new, protein-based vaccine against the original version of the...

The pharmaceutical company Pfizer has voluntary recalled a blood pressure medication for the second time in a month. Pfizer is recalling five lots of blood pressure medicine Accupril because of elevated levels of a nitrosamine, Nnitroso-quinapril, the company said in a news release posted Friday on the FDA website. Nitrosamines...

Unfortunately, the 27-year-old mother and the 31-year-old father say their baby daughter has months to live. The 1-year-old child is suffering from a rare condition which was caused by a gene defect both parents carry. The parents knew something was wrong with their child when the baby started to go off her food at six weeks. The baby also started to lose weight, the couple said. The condition was confirmed with genetic testing and the doctors said it affects her ability to absorb the nutrients she needs from food. The condition is so rare it is thought to only occur in one in 79,000,000 people, the doctors said.

MILLIONS of Brits have been urged to take up a rapid test to see if they have bowel cancer. The Health Secretary has called on men over 60 to make sure they have the life-saving checkups. It couldn't be easier - with a home testing kit on offer, or use...

Walking at a brisk pace for just 75 minutes every week could cut your risk of depression, a new study finds. The World Health Organization recommends everyone should exercise for at least two-and-a-half hours every seven days. But researchers at Cambridge University, England, found adults who got half as much...

Christine Bronstein took at home colon cancer test after seeing blood in her stool. It was positive, but her doctor texted: "You don't have cancer :)"

In a follow-up on the 14th Ebola Virus Disease (EVD) outbreak in the Democratic Republic of the Congo (DRC) (HERE and HERE), the World Health Organization (WHO) tweeted today:. Health authorities in #DRC confirmed a 2nd case of #Ebola in Mbandaka on 25 April. The 25-year old woman, now deceased, began experiencing symptoms 12 days earlier. Investigations indicate that as the 1st case patient’s sister-in-law, she was a high-risk contact.

Shielding those vulnerable to COVID-19, while allowing the virus to spread, largely unmitigated, through the rest of the population, would have failed according to a new modeling paper published today in PLOS Global Public Health by University of Bath scientists. Shielding strategies or "focused protection", as advocated for in the...

The emergence of COVID-19 had doctors racing to define and treat the new disease, but they soon discovered it was not the only novel illness caused by SARS-CoV-2. A subset of children infected by the virus also experienced abdominal pain, headaches, rashes and vomiting. This new set of symptoms was labeled multisystem inflammatory syndrome in children (MIS-C) and had many of its pediatric patients requiring intensive care.

A global study of asthma patients by Rutgers and an international team of researchers found a combination of two drugs dramatically reduces the chances of suffering an asthma attack. Results from the clinical trial called MANDALA, published in The New England Journal of Medicine, show that a combination of albuterol,...

Researchers from the Centenary Institute and the University of Technology Sydney have published the first study showing why people with chronic obstructive pulmonary disease (COPD) are at higher risk of developing severe COVID-19. The findings, reported in the American Journal of Respiratory and Critical Care Medicine, could lead to the...

The rapid development and deployment of COVID vaccines has been one of the greatest achievements of the pandemic. However, Australia risks relying on COVID vaccines from two main companies—Pfizer and Moderna—and that's a problem. While the need for COVID vaccines is not going away anytime soon, we need...

For immunosuppressed patients, mRNA-1273 induces a stronger seroresponse than BNT162b2, according to a research letter published online May 16 in JAMA Network Open. Jonathan Mitchell, M.B.B.S., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues compared antispike antibody titers after two-dose mRNA-1273 and BNT162b2 vaccines in immunosuppressed patients with rheumatic and musculoskeletal diseases (RMDs) and solid organ transplant recipients (SOTRs). Participants received two mRNA doses between Dec. 16, 2020, and July 6, 2021. At 15 to 45 days after the second dose, semiquantitative testing for antibodies against the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 spike protein was performed.

The first study to look at follow-up for patients deemed at high risk for lung cancer after CT screening found that 47 percent delayed follow-up care, according to research published at the ATS 2022 international conference. "The fact that nearly half of all patients with abnormal findings in our study...

Redness, swelling and pain are signs of inflammation. It serves to protect the body from pathogens and foreign substances. Researchers from the Universities of Bonn and Cologne were able to show that inflammatory reactions of an important sensor protein proceed in a specific spatial direction. This finding has the potential to conceivably stop inflammation at the "growing end," and thus bring chronic inflammatory diseases to a halt. The study has now been published in the journal Science Advances.

Ultra-powerful 7T MRI scanners could be used to help identify those patients with Parkinson's disease and similar conditions who are most likely to benefit from new treatments for previously-untreatable symptoms, say scientists. Both Parkinson's disease and a related disorder, progressive supranuclear palsy (PSP), are progressive brain diseases that not only...