Researchers identify novel pathways responsible for liver cancer

A combination of two existing skin cancer drugs and a third experimental drug could lead to a new strategy for treating patients who do not respond to existing therapies, a new study in mice suggests. The researchers found that the triple therapy cured 100 percent of the mice in the...

Over the past decade, researchers have made great strides in the development and administration of cancer immunotherapies, which use the body's own immune system to treat disease. However, the therapies don't work for every person or with every type of cancer, and gaps in our understanding of exactly how the body mounts an anti-cancer immune response has slowed progress toward making them universally effective.

A team of researchers affiliated with multiple institutions in the U.S. and one in Japan has developed a new type of vaccine that helps the immune system destroy cancerous tumors by overcoming their defense system. In their paper published in the journal Nature, the group describes the new vaccine and its effects in mouse and rhesus macaque models.

Initial study results show that an experimental drug, called nemvaleukin alfa, when used alone or in combination with another anticancer drug (pembrolizumab) may be effective in treating several types of late-stage cancers in some patients. Both drugs are immunotherapies, medications designed to help the body's immune defense system detect and...

A team of researchers led by NTU scientists have discovered why patients with non-alcoholic fatty liver disease (NAFLD) are at higher risk of cardiovascular disease, thus shedding light on why the leading cause of mortality in NAFLD patients is cardiovascular complications instead of liver damage. The researchers found that NAFLD...

A special type of MRI found lung abnormalities in patients who had previously had COVID-19, even those who had not been hospitalized with the illness, according to a new study published in the journal Radiology. "In a collaboration between the University of Oxford and the University of Sheffield, we have...

An FDA-approved drug to lower blood sugar in adults with type 2 diabetes also may decrease blood vessel dysfunction associated with aging, according to a new study from the University of Missouri School of Medicine. Researchers initially examined the role aging plays in human blood vessel function and stiffness. Then...

A recent study jointly conducted by the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and the Faculty of Medicine, The Chinese University of Hong Kong (CU Medicine) shows that vaccinated individuals can develop more robust and broadly reactive antibody responses against SARS-CoV-2 variants than unvaccinated individuals after an omicron infection. This highlights the need for COVID-19 vaccination for unvaccinated people even after an SARS-CoV-2 infection. The findings are now published in Eurosurveillance.

Scientists have demonstrated that normal brain aging is accelerated by approximately 26% in people with progressive type 2 diabetes compared to individuals without the disease, reports a study published today in eLife. The authors evaluated the relationship between typical brain aging and that seen in type 2 diabetes, and observed...

A study led by experts from NHS Golden Jubilee and the University of Glasgow into the effects of COVID-19 on Scottish patients in Intensive Care Units (ICUs) has confirmed evidence that the virus is associated with impaired function of the right side of the heart. Specialists at NHS Golden Jubilee's...

Atherosclerosis, a buildup of plaque, can lead to heart disease, artery disease, and chronic kidney disease and is traditionally treated by inserting and inflating a balloon to expand the artery. Other treatments based on lasers can remove blockages rather than simply compressing them but are used infrequently, because they have a high risk of complication and low efficacy.

For more than 20 years, scientists have known that people with hypertension, diabetes, high cholesterol, or obesity have a higher likelihood of developing Alzheimer's disease. The conditions can all affect the brain, damaging blood vessels and leading to strokes. But the connection between vascular disease in the brain and Alzheimer's has remained unexplained despite the intense efforts of researchers.

Prone positioning does not significantly reduce the risk of intubation in hospitalized patients experiencing acute hypoxemic respiratory failure from COVID-19, according to the COVI-PRONE trial. However, patients receiving high-flow oxygen may benefit from awake prone positioning. This international, multi-center randomized clinical trial also found that prone positioning had no significant effect on death and the length of stay in the intensive care unit or hospital.

In Northwest Ethiopia, 35 percent of patients with dyspepsia have peptic ulcer disease, with risk factors including Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID)/acetylsalicylic acid (ASA) use, according to a study published online April 5 in BMC Gastroenterology. Belete Assefa, from the University of Gondar in Ethiopia,...

Colonoscopies performed with computer-aided detection, or artificial intelligence, (AI) saw an increase in the overall rate of detection of adenoma, or cancerous and precancerous polyps, by 27% in average-risk patients, according to new data presented today at the Digestive Disease Week Annual Meeting. The results of the prospective, randomized, multicenter...

Even vaccinated people with mild breakthrough COVID-19 infections can experience debilitating, lingering symptoms that affect the heart, brain, lungs and other parts of the body, according to new research from Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care System. The study of...

Researchers have shown how moderate egg consumption can increase the amount of heart-healthy metabolites in the blood, publishing their results today in eLife. The findings suggest that eating up to one egg per day may help lower the risk of developing cardiovascular disease. Eggs are a rich source of dietary...

Our brains rarely record single memories—instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time. As we age, however, our brains gradually lose this ability to link related memories. Now UCLA researchers have discovered a key molecular...

The risk of having a future stroke caused by a severe blockage in an artery in the neck that is not currently causing any symptoms is so low that most patients with this condition—asymptomatic carotid stenosis—could potentially be treated with the newest medications and may not require surgery, new Kaiser Permanente research suggests.

Use of electronic (e) cigarettes appears to lead to substantially higher costs and excess use of healthcare services in the USA, suggests new research published in the journal Tobacco Control. Popularity of e-cigarettes as an alternative to traditional cigarettes and other tobacco products has grown in recent years with current...