Cancer therapy using on-site synthesis of anticancer drugs

MILLIONS of Brits have been urged to take up a rapid test to see if they have bowel cancer. The Health Secretary has called on men over 60 to make sure they have the life-saving checkups. It couldn't be easier - with a home testing kit on offer, or use...

Christine Bronstein took at home colon cancer test after seeing blood in her stool. It was positive, but her doctor texted: "You don't have cancer :)"

An article published in Scientific Reports describes a study demonstrating the effectiveness of a peptide developed by Brazilian scientists, called Rb4, in combating cancer progression in an animal model, especially malignant melanoma. The molecule holds promise for the treatment of drug-resistant tumors. Preclinical in vitro and in vivo trials indicated...

An international team of researchers led by University College Dublin (UCD) have uncovered a potential treatment approach for advanced uveal melanoma (UM), a type of cancer that effects the eye. Uveal melanoma is the most common adult eye cancer. UM begins in the iris, ciliary body or choroid (collectively known...

Northwestern Medicine investigators have discovered a potential therapeutic target for the most common type of pancreatic cancer, according to a study published in Developmental Cell. The findings suggest ISL2, a transcription factor, can act as a tumor suppressor in pancreatic ductal adenocarcinoma (PDA) tumors and that its depletion reprograms PDA...

The pharmaceutical company Pfizer has voluntary recalled a blood pressure medication for the second time in a month. Pfizer is recalling five lots of blood pressure medicine Accupril because of elevated levels of a nitrosamine, Nnitroso-quinapril, the company said in a news release posted Friday on the FDA website. Nitrosamines...

Though helpful for cleaning and disinfecting, Lysol contains a number of harmful chemicals that can irritate your eyes, skin, and respiratory system.

Walking at a brisk pace for just 75 minutes every week could cut your risk of depression, a new study finds. The World Health Organization recommends everyone should exercise for at least two-and-a-half hours every seven days. But researchers at Cambridge University, England, found adults who got half as much...

Tragic events like wars, famines, earthquakes, and accidents create fearful memories in our brain. These memories continue to haunt us even after the actual event has passed. Luckily, researchers from Tokyo University of Science (TUS) have recently been able to understand the hidden biochemical mechanisms involved in the selective suppression of fearful memories, which is called fear extinction. The researchers, who had previously demonstrated fear extinction in mice using the chemically synthesized compound "KNT-127," have now identified the underlying mechanism of this compound's action. Their findings have been published recently in Frontiers in Behavioral Neuroscience.

Infantile spasm (IS) is a severe epileptic syndrome of infancy and accounts for 50% of all epilepsy cases that occur in babies during the first year of life. Current treatment options for this disorder are limited and most affected infants grow up to have developmental delays, intellectual disabilities and other types of severe epilepsy. A groundbreaking study, conducted in the laboratory of Dr. John Swann, director of the Gordon and Mary Cain Pediatric Neurology Research Foundation labs, investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and professor at Baylor College of Medicine, has found that the levels of insulin growth factor -1 (IGF-1) and its downstream signaling are reduced in the brains of both IS patients and animal models. Furthermore, they found that the administration of an IGF-1 analog to an IS animal model successfully eliminated spasms and abnormal brain activity. This exciting study, published in the Annals of Neurology, has the potential to transform the treatment landscape for babies with infantile spasms.

Children who spend more time playing adventurously have lower symptoms of anxiety and depression, and were happier over the first COVID-19 lockdown, according to new research. A study led by the University of Exeter asked parents how often their children engaged in play that was "thrilling and exciting", where they might experience some fear and uncertainty.

There is increasing recognition of the important role sleep plays in our brain health. Growing evidence suggests disturbed sleep may increase the risk of developing dementia. I and University of Sydney colleagues have published a new study showing treating sleep apnea in older adults with mild cognitive impairment can improve memory, but not other areas of cognition, in the short term.

Patients who use cannabis required higher levels of sedation during gastric endoscopies than non-users, according to research to be presented at Digestive Disease Week (DDW) 2022. As cannabis is legalized in more places and usage rises, clinicians should be aware of patients' habits and prepare themselves and their patients for increased sedation and accompanying risks, researchers said.

People who reported in a survey that they felt worried, depressed or lonely had a greater chance of being hospitalized after a COVID-19 diagnosis, suggests a study funded by the National Institutes of Health. The study, which analyzed survey data from more than 54,000 female nurses and their offspring, was conducted by Andrea L. Roberts, Ph.D., of the Harvard T. H. Chan School of Public Health, Boston, and colleagues. It appears in Psychological Medicine.

A woman suffering from what's being described as a "rare disease" visited her doctor in January and received a shock when she noticed a $40 charge for crying on her itemized invoice. Grouped in with standard charges for a vision assessment test, hemoglobin test, health risk assessment and capillary blood...

DEAR MAYO CLINIC: I have been diagnosed with a mild case of irritable bowel syndrome, and I talked to my doctor about managing my symptoms without medication. I am interested in trying to focus more on diet to control my condition. Are there certain things that I should be mindful of, or will medication be the only way for me to manage my symptoms?

Scientists at St. Jude Children's Research Hospital have solved an immunology puzzle. A CD8+ T cell can have two functionally distinct daughter cells after it divides, despite the cells being genetically identical. The researchers have explained how, revealing one method the immune system uses to provide immediate and long-term protection. The research appears today in Molecular Cell.

Scientists from the University of Birmingham have shown an existing drug may reduce damage after spinal cord injury, by blocking the inflammatory response in the spinal cord. Their research, published today in Clinical and Translational Medicine, demonstrates that AZD1236, a drug developed by AstraZeneca, can significantly reduce "secondary damage" caused by the body's response to spinal cord injury (SCI).

In the mid-20th century, new evidence showed that the brain could be "plastic," and that experience could create changes in the brain. Plasticity has been linked to learning new skills, including spatial navigation, aerobic exercise and balance training. Yet it has remained an open question whether mindfulness interventions, like meditation,...

A multicenter study performed by a large international consortium that includes UT Southwestern has outlined a set of risk factors and outcomes for patients with autoimmune hepatitis (AIH) that recurs after liver transplantation. The findings, published in the Journal of Hepatology, represent a first step toward better managing and potentially preventing this uncommon condition.