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Ethnically diverse cancer cell lines for drug testing

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The current modus operandi for cell line use results in poor translatability in clinical trials. To improve this, continually producing a wider cross-section of cell lines, capturing different grades and stages of tumours among different ethnic groups, with an urgent focus on Black people, is key to a targeted approach.

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References

  1. Kunnumakkara, A. B. et al. Cancer drug development: the missing links. Exp. Biol. Med. 244, 663–689 (2019).

    Article  CAS  Google Scholar 

  2. Badal, S. The first caribbean cell line, ACRJ-PC28. Presented at the 2021 14th AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved (2021).

  3. Schepartz, S. A. History of the National Cancer Institute and the plant screening program. Cancer Treat. Rep. 60, 975–977 (1976).

    CAS  PubMed  Google Scholar 

  4. Abbott, B. J., Hartwell, J. L., Leiter, J., Spetzman, L. A. & Schepartz, S. A. Screening data from the cancer chemotherapy national service center screening laboratories. XXXI. Plant extracts. Cancer Res. 27, 364–527 (1967).

    CAS  PubMed  Google Scholar 

  5. Meštrović, T. Paclitaxel History. News Medical Life Sciences https://www.news-medical.net/health/Paclitaxel-History.aspx (2021).

  6. Pettengill, O. S. et al. Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung. Cancer 45, 906–918 (1980).

    Article  CAS  Google Scholar 

  7. Grenade, C., Phelps, M. A. & Villalona-Calero, M. A. Race and ethnicity in cancer therapy: what have we learned? Clin. Pharmacol. Ther. 95, 403–412 (2014).

    Article  CAS  Google Scholar 

  8. Pastina, I. et al. Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients. BMC Cancer 10, 511 (2010).

    Article  Google Scholar 

  9. Badal, S. A. M. et al. Glaucarubulone glucoside from Castella macrophylla suppresses MCF-7 breast cancer cell growth and attenuates benzo[a]pyrene-mediated CYP1A gene induction. J. Appl. Toxicol. 37, 873–883 (2017).

    Article  CAS  Google Scholar 

  10. William, L. A., Rosner, H., Levy, H. G. & Barton, E. N. A critical review of the therapeutic potential of dibenzyl trisulfide isolated from Petveria alliacea L (guinea hen weed, anamu). West Indian Med. J. 56, 17–21 (2007).

    Google Scholar 

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Correspondence to Simone Badal.

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Badal, S. Ethnically diverse cancer cell lines for drug testing. Nat Rev Cancer 22, 65–66 (2022). https://doi.org/10.1038/s41568-021-00440-3

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