Jefferson (illness) doesn't have a designation for Sunday's game in Denver, Tim Twentyman of the Lions' official site reports.
Jefferson was affected by the flu outbreak going around the Lions' locker room, with the Lions holding him out of drills Thursday. But he was able to handle every practice rep to cap the week and set himself up to be available Sunday. The same can't be said for D'Andre Swift, who is missing a second consecutive game due to an AC joint sprain, and Jamaal Williams, whom the Lions placed on the reserve/COVID-19 list Friday. With Swift and Williams sidelined this weekend, Jefferson and Godwin Igwebuike will handle running back duties for Detroit.