The Massachusetts Department of Public Health reported an additional 5,403 confirmed COVID-19 cases on Wednesday.The state's seven-day positivity rate is 4.99 percent, nearly triple the level reported on Nov. 1, when the positivity rate was 1.75 percent. According to Wednesday's report from the DPH, 1,204 patients with confirmed coronavirus cases were hospitalized in Massachusetts, of which 252 were reported to be in an intensive care unit.The 7-day average of hospitalizations stands at 1,064, more than double what the seven-day average was in early November. In recent days, the number of patients hospitalized has sharply increased. The seven-day average of hospitalizations was 855 on Dec. 1. When will doctors learn more about omicron coronavirus variant? Mass. doctor explainsState health officials said 417 of the patients in Massachusetts hospitals are COVID-19 breakthrough cases. A breakthrough case is when an individual tests positive for COVID-19 after they've been fully vaccinated against the disease.State health officials also added 12 confirmed COVID-19-related death to the state's total, which is now 19,163.More than 4.9 million of Massachusetts' 7.03 million residents are now fully vaccinated against COVID-19, according to the DPH.Massachusetts COVID-19 cases, hospitalizations and fatalitiesMassachusetts vaccination progressNew data is typically published weekdays around 5 p.m., with weekend data included in Monday's report. Weekly data reports are typically released on Thursdays at around 5 p.m.