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Toxicity of internalized polyalanine to cells depends on aggregation

Nature.com
 2021-12-06

Cover picture for the articleIn polyalanine (PA) diseases, the disease-causing transcription factors contain an expansion of alanine repeats. While aggregated proteins that are responsible for the pathogenesis of neurodegenerative disorders show cell-to-cell propagation and thereby exert toxic effects on the recipient cells, whether this is also the case with expanded PA has not been studied....

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