Scientists find the cause of severe disease and death in COVID-19

Knowridge Science Report
Knowridge Science Report
Credit: CC0 Public Domain

In a recent study published in Cell Metabolism, researchers found COVID-19 may bring high risks of severe disease and death in many patients by disrupting key metabolic signals and thereby triggering high blood sugar.

They found that high blood sugar is common in hospitalized COVID-19 patients and is strongly linked to worse outcomes.

The researchers also found evidence suggesting that SARS-CoV-2, the coronavirus that causes COVID-19, can induce hyperglycemia by disrupting fat cells’ production of adiponectin, a hormone that helps regulate blood sugar levels.

The study is from Weill Cornell Medicine. One author is Dr. James Lo.

High blood sugar, the core feature of diabetes, is associated with inflammation and weakened immunity against infections, and was recognized as a significant risk factor for severe COVID-19 early in the pandemic.

However, doctors later began finding evidence that COVID-19 is associated with hyperglycemia in patients who have no history of diabetes.

In the study, the team analyzed the records of 3,854 patients in the first few months of the pandemic in the United States.

They found that a remarkably high proportion (49.7%) of these patients presented with high blood sugar or developed it during their hospital stays.

High blood sugar in these COVID-19 patients was also strikingly linked to worse outcomes.

Compared to patients with normal blood sugar levels, the patients with high blood sugar were 9 times more likely to develop severe lung dysfunction (acute respiratory distress syndrome, or ARDS), 15 times more likely to be given mechanical ventilation, and 3 times more likely to die.

Hyperglycemia in COVID-19 patients is mainly caused by insulin resistance, in which insulin is present but the tissues it normally acts upon are no longer sensitive to it

Further tests revealed that the COVID-19 ARDS patients had severe declines in blood levels of adiponectin, a hormone produced by fat cells which normally has a protective effect against diabetes by enhancing insulin sensitivity.

The team says patients with obesity, for example, may be more vulnerable to COVID-19 because they may already have some degree of insulin resistance and fat cell dysfunction, and possibly their fat cells are more susceptible to infection.

The findings also suggest that a class of diabetes drugs called thiazolidinediones, which boost adiponectin production, may be useful in treating COVID-19 when it includes hyperglycemia. Further research is needed before this becomes clinically actionable.

If you care about COVID, please read studies about the nose shows why some people get severe COVID-19 and findings of why are we seeing more COVID cases in fully vaccinated people?

For more information about COVID and your health, please see recent studies about this drug could inhibit COVID-19 virus, may help treat infections and results showing that this drug duo that may treat COVID-19 effectively.

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Comments / 337

Marcell Nowotny Ammon

Just goes to show how much the government cares about its people. After all they made the virus, they had their fingers in the jabs. I wish I could understand why countries do this to their own citizens.


Do you know what else kills covid patients? The treatment!!! Remdesavir is the standard treatment for hospitalized patients. Remdesavir causes organ failure, starting with the kidneys. When this happens, doctors pump the patient full of fluids. The fluids drown their organs and their lungs fill with fluid. Then they die. And when they’re on their deathbed, and the patient and their family requests ivermectin, doctors refuse and just let the patients die. Why not allow a dying patient to try anything? Because they don’t want anyone to know that a safe, inexpensive treatment can work. They’d rather you die!!! Recently, a man on his deathbed won a court case ordering the hospital to give him ivermectin. Within hours, he felt better. Within two weeks, he went home. Believe it!! It’s true!!!

Kim Watkins

not overweight and never had high blood sugar levels. recovered from covid and now my blood sugar is higher and put me in the pre diabetic category. my doctor was actually shocked to see my chlorestrol and blood sugar levels elevated this blood test.


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