The Canucks have scored three goals in their past three games and more than three goals in one of their past nine games.
"I thought it was one of our better games of the year," Vancouver coach Travis Green said. "We were on our game. Our details were sharp. I give them a lot of credit. They played a tough game and they're going to have to bounce back. It's tough to lose when you play well, especially when things are going the way they are."
Adam Boqvist put the Blue Jackets ahead 2-1 at 6:17 of the second period, scoring from a low angle on the right side on a rebound of a Cole Sillinger shot.
Motte made it 2-2 at 18:42. The former Blue Jackets forward scored his first of the season with a tip of a shot from the blue line by Quinn Hughes.
"You're not going to complain when you had the puck as much as we did," Green said.
The shot attempt were 47-16 and shots on goal 28-9 at that point.
"Some nights you see more quality than quantity and they don't go in, and other nights it's the reverse," Motte said. "But either way you've got to find a way to put the puck in the net."
Max Domi scored into an empty net with 1:35 left in the third period to make it 4-2.
"Right now, it doesn't matter if we played well or didn't play well, we lost," Canucks forward Conor Garland said.
Merzlikins was aided by 19 blocked shots, six by defenseman Jake Bean.
"I know the boys are there," Merzlikins said. "Even if they are going to be tired, they will still stop the shots for me. They will try their best."