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Antihistamines can influence immunotherapy response by enhancing T cell activation

MedicalXpress
 2021-11-24

Cover picture for the articleNew research from The University of Texas MD Anderson Cancer Center found that treatment with antihistamines, a commonly used allergy medication, was associated with improved responses to immune checkpoint inhibitors. The preclinical study demonstrated that the histamine receptor H1 (HRH1) acts in tumor-associated macrophages (TAMs) to suppress T cell activation in...

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