Mehki Lairy added 13 points and matched a career high with assists. Precious Ayah and Kamari Wiliams chipped in 13 points apiece, while Dalone Brown and Isaiah Coleman-Lands added 10 each. All 13 RedHawks who played scored.
Miami shot 56.3% from the field while holding Defiance to 28.6%.
The RedHawks travel to Western Illinois for a 3 p.m. tip on Saturday.
SATURDAY’S GAME
Miami at Western Illinois, 3 p.m., 980, 1450