Buffalo Bills quarterback Josh Allen (17) is tackled by Indianapolis Colts defensive tackle Antwaun Woods (96) during the first half of an NFL football game in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Indianapolis Colts running back Jonathan Taylor (28) dives into the end zone during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts running back Jonathan Taylor (28) falls into the end zone for his second touchdown of the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Buffalo Bills quarterback Josh Allen (17) throws a pass during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts quarterback Carson Wentz (2) scrambles with the ball during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Indianapolis Colts defensive back George Odum (30) runs after intercepting a pass intended for Buffalo Bills wide receiver Stefon Diggs (14) during the first half of an NFL football game in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Indianapolis Colts defensive back George Odum (30) celebrates after intercepting a pass during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts quarterback Carson Wentz (2) throws a pass during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Indianapolis Colts quarterback Carson Wentz (2) begins to slide after a scramble with the ball during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Buffalo Bills quarterback Josh Allen (17) scrambles with the ball during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Buffalo Bills quarterback Josh Allen (17) looks to pass during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Wide receiver (19) Isaiah McKensie of the Buffalo Bills fumbles a kickoff against the Indianapolis Colts in an NFL football game, Sunday, Nov. 21, 2021, in Orchard Park, NY. (AP Photo/Jeff Lewis)
Indianapolis Colts quarterback Carson Wentz (2) looks to throw a pass during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Buffalo Bills head coach Sean McDermott gestures toward an official during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Tight end (88) Dawson Knox of the Buffalo Bills scores a touchdown and as a celebration, is photographed by Stefon Diggs against the Indianapolis Colts in an NFL football game, Sunday, Nov. 21, 2021, in Orchard Park, NY. (AP Photo/Jeff Lewis)
Running back (28) Jonathan Taylor of the Indianapolis Colts runs the ball against the Buffalo Bills in an NFL football game, Sunday, Nov. 21, 2021, in Orchard Park, NY. (AP Photo/Jeff Lewis)
Running back (28) Jonathan Taylor of the Indianapolis Colts leaps for a touchdown against the Buffalo Bills in an NFL football game, Sunday, Nov. 21, 2021, in Orchard Park, NY. (AP Photo/Jeff Lewis)
Buffalo Bills quarterback Josh Allen (17) scrambles during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Indianapolis Colts running back Jonathan Taylor (28) dives into the end zone for a touchdown during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Quarterback (17) Josh Allen of the Buffalo Bills passes the ball against the Indianapolis Colts in an NFL football game, Sunday, Nov. 21, 2021, in Orchard Park, NY. (AP Photo/Jeff Lewis)
Indianapolis Colts kicker Mike Badgley (6) celebrates kicking an extra point with Rigoberto Sanchez (8) during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts running back Jonathan Taylor (28) scores during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts running back Jonathan Taylor (28) scores during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts head coach Frank Reich greets his god daughter on the field during warmups before an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts running back Jonathan Taylor (28) carries the football during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts running back Jonathan Taylor (28) carries the football during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts running back Jonathan Taylor (28) carries the football during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts quarterback Carson Wentz (2) gets off a pass under pressure from Buffalo Bills defensive end Jerry Hughes (55) during the first half of an NFL football game in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Buffalo Bills quarterback Josh Allen (17) scrambles with the ball during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts running back Jonathan Taylor (28) gets past Buffalo Bills outside linebacker A.J. Klein (54) to score during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. It was Taylor's second touchdown of the game. (AP Photo/Adrian Kraus)
Buffalo Bills quarterback Josh Allen (17) gets off a shuffle pass during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Buffalo Bills running back Devin Singletary (26) is tackled by Indianapolis Colts middle linebacker Bobby Okereke (58) during the first half of an NFL football game in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
After scoring a touchdown, Buffalo Bills wide receiver Stefon Diggs (14) celebrates with teammate Dawson Knox during the first half of an NFL football game against the Indianapolis Colts in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Jeffrey T. Barnes)
Indianapolis Colts running back Jonathan Taylor (28) carries the football during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
Indianapolis Colts running back Jonathan Taylor (28) gets past Buffalo Bills cornerback Taron Johnson (24) en route to the end zone for a touchdown during the first half of an NFL football game in Orchard Park, N.Y., Sunday, Nov. 21, 2021. (AP Photo/Adrian Kraus)
In a rematch from last season’s AFC Wild Card playoff, the Buffalo Bills return to Highmark Stadium in Orchard Park, N.Y., to take on the Indianapolis Colts.
Kickoff is at 1 p.m.
The Colts are 5-5 and coming off a 23-17 home win over the Jacksonville Jaguars. Carson Wentz was 22-for-34 passing for 180 yards, while Jonathan Taylor rushed for 116 yards and a touchdown. The Colts’ special teams unit came up big, returning a blocked punt for a touchdown.
The Bills bounced back from a disappointing loss to the Jaguars in Week 9 to crush the New York Jets 45-17 last week. Four different players ran for touchdowns for Buffalo, while Stefon Diggs caught 8 passes for 162 yards and a score. The Bills defense intercepted New York quarterback Mike White four times.
See in-game team and individual stats here.
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