The Indianapolis Colts, coming off a scrappy win in Week 10 against the Jacksonville Jaguars, square off with the Buffalo Bills, who lost to the Jags the week before, this week in a Sunday matinee. Given that both of these contending teams just had tough games against one of the league's worst teams on paper, we're coming into this game with a lot of bold predictions in mind.

On the Colts' side, they're coming off yet another game where Jonathan Taylor had a monster performance to lead them to victory. He moved into first in the league in rushing yards as he racked up 116 yards on 21 carries. Shockingly, that was the first game all season that he's seen 20 more carries in a game.

For more insight on the Colts' Week 11 matchup against the Bills, listen below:

Carson Wentz played mistake-free football as well, throwing for 180 yards on 22/34 passing, with no touchdowns or interceptions. He'll have to step it up a bit more this game against Buffalo, however, as they've got the top-ranked defense in the NFL.

Do the Colts have the juice to take down the juggernaut that is the Bills? Or will Buffalo keep rolling after drubbing the Jets 45-17 last week? Here are 4 bold predictions for this contest.

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Colts Week 11 Predictions

4. Jonathan Taylor is unaffected by Bills run D, tops 100 yards again

Taylor has averaged an absurd 5.8 yards per carry this year, which will be tough to keep up against the Bills, who have allowed only 3.8 yards per carry, good for third in the NFL. However, there may not be another talent in the league like Taylor right now. He has an unrivaled combination of speed, agility, and durability that makes for pure magic behind the solid Colts O-line. No defense can stop him right now.

3. Darius Leonard goes crazy for sack, interception of Josh Allen

Leonard, the two-time All-Pro linebacker and lynchpin of this defense, has never failed to produce for Indy. He has two interceptions already this season, but doesn't have any sacks yet. There's yet to be a season in which Leonard has failed to reach at least 3 sacks, and he's due for a big game where Matt Eberflus unleashes him on some delayed blitzes.

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GM Chris Ballard in the middle, Jared Verse, Troy Franklin, Jaden Hicks around him, and Indianapolis Colts wallpaper in the background

Enzo Flojo ·

2. Carson Wentz and Michael Pittman link up for 2 touchdowns

The writing was on the wall for Pittman to have a huge breakout season this year as long as he got some solid quarterback play, and that has sure come to fruition. He's averaging over 70 yards per game and has caught 5 touchdowns, firmly establishing himself as the Colts new best receiver. Even despite the relative lack of volume this offense has through the air, Pittman seems like he's always going to get his. Big game incoming.

1. Colts pull off wild upset in overtime

The Bills are loaded with talent on paper, but this Colts team is one to watch out for as well. They've had dominant showings in recent weeks, and showed, even in their losses, that they're a force to be reckoned with and never give an easy game. With constant pressure on Josh Allen and a dominant run game, they'll pull out an upset.

PREDICTION: Colts 27, Bills 21