A London derby sees West Ham take on Tottenham while Brentford host Leicester City in the Premier League on Sunday afternoon.
Both Spurs and the Hammers can climb above Brighton and move into the top four if they take the three points and local bragging rights at the London Stadium.
The Bees, meanwhile, will be hoping to continue their excellent start to life in the top division against a Leicester side who beat Man United last weekend.
Follow Sportsmail's TOBY MILES for live Premier League coverage of West Ham vs Tottenham, including build-up, team news and updates.