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Biomimetic enantioselective synthesis of β,β-difluoro-α-amino acid derivatives

Nature.com
 2021-10-22

Cover picture for the articleAlthough utilization of fluorine compounds has a long history, synthesis of chiral fluorinated amino acid derivatives with structural diversity and high stereoselectivity is still very appealing and challenging. Here, we report a biomimetic study of enantioselective [1,3]-proton shift of β,β-difluoro-α-imine amides catalyzed by chiral quinine derivatives. A wide range of corresponding...

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