Montreal Canadiens at Buffalo Sabres (7 p.m. ET; MSG-B, TSN2, RDS, ESPN+, NHL LIVE)
The Canadiens will try to rebound after opening the season with a 2-1 loss at the Toronto Maple Leafs on Wednesday. Montreal forward Jonathan Drouin scored in his first game since taking leave April 28 because of insomnia brought on by anxiety. Sabres coach Don Granato said he expects Drake Caggiula to be in the lineup. The forward skated with Buffalo on Wednesday, one day after leaving practice early following a collision along the boards.
Toronto Maple Leafs at Ottawa Senators (7 p.m. ET; TSN5, RDS2, TSN4, ESPN+, NHL LIVE)
Goalie Petr Mrazek could make his Maple Leafs debut after Toronto opened its season with a 2-1 win against the Canadiens on Wednesday. Mrazek signed a three-year, $11.4 million contract with the Maple Leafs on July 28. It's the season opener for the Senators, who are expecting a capacity crowd.
Pittsburgh Penguins at Florida Panthers (7 p.m. ET; SN360, BSFL, ATTSN-PT, ESPN+, NHL LIVE)
The Penguins go for their second straight win to start the season following a 6-2 victory at the Lightning on Tuesday. Goalie Sergei Bobrovsky will start for the Panthers in their season opener.
Dallas Stars at New York Rangers (7 p.m. ET; MSG, BSSW, ESPN+, NHL LIVE)
The Rangers play for the second time in as many nights following a season-opening 5-1 loss at the Washington Capitals on Wednesday. The Stars are hoping forward Alexander Radulov will be healthy enough to play in their season opener after he was held out of practice Wednesday because of a non-COVID illness.
New York Islanders at Carolina Hurricanes (7 p.m. ET; TVAS, BSSO, MSG+, ESPN+, NHL LJVE)
Frederik Andersen will make his Hurricanes debut after the goalie signed as a free agent. It's the first of 13 straight road games to start the season for the Islanders, who will move into UBS Arena in Elmont, New York, next month.
Arizona Coyotes at Columbus Blue Jackets (7 p.m. ET; BSOH, BSAZ, ESPN+, NHL LIVE)
Andre Tourigny debuts as Coyotes coach after three seasons in the same capacity with Ottawa of the Ontario Hockey League. Brad Larsen does the same for Columbus, replacing John Tortorella. He was an assistant the previous seven seasons.
Tampa Bay Lightning at Detroit Red Wings (7:30 p.m. ET; BSDET, BSSUN, ESPN+, NHL LIVE)
The Lightning aim to rebound following a 6-2 loss at home to the Penguins in their season opener. The Red Wings start their season with a four-game homestand.
Seattle Kraken at Nashville Predators (8 p.m. ET; NHLN, BSSO, ROOT-NW, ESPN+, NHL LIVE)
The Kraken rallied from down 3-0 in their first NHL game but fell short in a 4-3 loss at the Vegas Golden Knights on Tuesday. The Predators open their season after signing defenseman Mattias Ekholm to a four-year, $25 million contract Wednesday.
Vegas Golden Knights at Los Angeles Kings (10:30 p.m. ET; TVAS, BSW, ATTSN-RM, ESPN+, NHL LIVE)
Vegas aims to build on its season-opening 4-3 win against Seattle on Tuesday, when forward Max Pacioretty had two goals and an assist, and forward Mark Stone had three assists. Forward Phillip Danault is expected to make his Kings debut after signing a six-year, $33 million contract July 28.