The Chicago White Sox rallied from four runs down in Game 3 to stay alive in the 2021 ALDS with a 12-6 win, and will look to even the series at 2-2 when they take on the Houston Astros in Game 4 on Tuesday afternoon. Monday's game was rained out. Trailing 5-1 in the third, Chicago scored five times to flip momentum and now have a chance to send the series back to Houston on even ground. The Astros (95-67), who have earned five consecutive trips to the postseason, are looking to advance to the American League Championship Series for the fifth consecutive season. The White Sox (93-69), who have made the postseason the past two seasons, look to advance to their first ALCS since 2005, the year they won the World Series.

The game is slated to begin at 2:07 p.m. ET from Guaranteed Rate Field in Chicago. Chicago is a -111 favorite (risk $111 to win $100) on the money line in the latest Astros vs. White Sox odds from Caesars Sportsbook, while the over-under for total runs scored is 8.5. Before making any White Sox vs. Astros picks, be sure to see the MLB playoff predictions and betting advice from SportsLine's proven model.

This model, which simulates every game 10,000 times, enters the second week of the 2021 MLB playoffs with a 207-175 record on top-rated MLB money-line picks, returning well over $700. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. Anyone following it has seen some huge returns.

Now, the model has set its sights on White Sox vs. Astros and revealed its MLB playoff 2021 picks and analysis. You can head to SportsLine now to see the picks. Here are several MLB playoffs odds and trends for Astros vs. White Sox:

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  • Astros vs. White Sox money line: Houston +101, Chicago -111
  • Astros vs. White Sox run line: Chicago -1.5 (+175)
  • Astros vs. White Sox over-under: 8.5
  • HOU: The Astros are 13-4 in their last 17 Tuesday games
  • CWS: The White Sox are 7-2 in their last nine games overall

Why you should back the White Sox

Chicago used its strong offense to stay alive in the series and will look to continue that momentum. Hot-hitting first baseman Jose Abreu has hits in all three games and is batting .417 in the series, going 5-for-12 with three RBIs. He was a .261 hitter during the regular season with 30 homers, 117 RBIs and 86 runs scored. In 42 career regular-season games against the Astros, Abreu has a .255 average with 10 doubles, six homers and 21 RBIs.

After missing a good portion of the season with a hip flexor injury, center fielder Luis Robert is making up for lost time. Robert was 3-for-4 with an RBI and a walk in Game 2, and is 6-for-12 in the series. In 68 regular-season games this season, Robert batted .338 with 13 homers, 43 RBIs and 42 runs scored. He has a four-game hitting streak and has hits in seven of his last nine games.

Why you should back the Astros

Houston is expected to send right-hander Lance McCullers Jr. (13-5, 3.16 ERA) to the mound. McCullers was the Game 1 winner, not allowing an earned run on four hits in 6 2/3 innings. He did not walk a batter and struck out four. He has won five of his last six decisions, including his last two starts.

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Shortstop Carlos Correa is having a solid series, going 3-for-9 with a double, two RBIs and four runs scored. He was 2-for-3 in Game 1. During the regular season, Correa batted .279 with 26 homers, 92 RBIs and 104 runs scored. In seven games against the White Sox, he had three extra-base hits, including two home runs.

How to make Astros vs. White Sox picks

The model is leaning over on the total, projecting nine combined runs. It also says one side of the money line has all the value. You can only get that pick at SportsLine

So who wins Astros vs. White Sox? And which side of the money line has all the value? Visit SportsLine now to find out which side of White Sox vs. Astros you need to jump on, all from the model that has crushed it MLB picks, and find out.  

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