New York Giants running back Saquon Barkley was carted off the field midway through the first quarter with a left ankle injury during Sunday's game against the Dallas Cowboys.

The Giants ruled him out for the rest of the game, and Ian Rapoport of NFL Network reported afterward that Barkley was believed to have suffered a low-ankle sprain, which could force him to only miss one week.

However, Rapoport later reported that Barkley could miss two to four weeks with the injury (40-second mark of the video):

There was some concern during the preseason about whether Barkley would be available when the regular season began, as he was recovering from a torn ACL that ended his 2020 season in Week 2.

Barkley's first practice with the team was Aug. 9, and the 24-year-old made it through camp without any setbacks and was in the lineup for Week 1 against the Denver Broncos, albeit on a limited basis. He did play over 80 percent of the team's snaps in each of their next two games.

The Giants need Barkley to play at the level he did in his first two seasons to have any chance of competing in 2021. In 2018 and 2019, he averaged 1,735 yards from scrimmage and 11.5 total touchdowns on 310.5 total touches.

Until Barkley is able to return, the 1-4 Giants will turn to Devontae Booker as their primary running back.