Philadelphia Eagles at Carolina Panthers odds, picks and prediction

Joe Williams
Sportsbook Wire

The Philadelphia Eagles (1-3) travel to meet the Carolina Panthers (3-1) at Bank of America Stadium Sunday of Week 5. Kickoff is scheduled for 1 p.m. ET and the game is televised on FOX. Below, we look at the Eagles vs. Panthers odds and lines, and make our best NFL picks, predictions and bets.

The Eagles came up short at home against the Kansas City Chiefs in Week 4, losing 42-30. Not only was it the third straight loss for Philly, it failed to cover the spread for the third consecutive outing, too. The Over cashed in each of the last two for the Eagles, as they yielded 83 total points.

The Panthers suffered their first setback of the season against the Dallas Cowboys in Week 4, falling 36-28 on the road. It was also the first non-cover for Carolina, and its first Over result after three consecutive Unders.

Eagles at Panthers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Saturday at 9:20 a.m. ET.

  • Money line: Eagles +133 (bet $100 to win $133) | Panthers -165 (bet $165 to win $100)
  • Against the spread (ATS): Eagles +3.5 (-130) | Panthers -3.5 (+105)
  • Over/Under (O/U): 45.5 (O: -115 | U: -105)

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Eagles at Panthers key injuries

Eagles

  • OT Lane Johnson (personal) out

Panthers

  • RB Christian McCaffrey (hamstring) doubtful
  • LB Shaq Thompson (foot) out
  • OT Cameron Erving (neck) out
  • DE Yetur Gross-Matos (ankle) questionable

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Eagles at Panthers odds, lines, predictions and picks

Prediction

Panthers 23, Eagles 20

Money line

Taking the PANTHERS (-165) straight up and forgetting about the laying the points isn't a bad idea. The cost for Carolina isn't terribly out of line.

Against the spread

The EAGLES +3.5 (-130) are worth a small-unit play. The Panthers aren't blowing anyone out, and it's not a good idea to lay the three and a hook, even at home.

I just don't trust Carolina's offense, especially without McCaffrey, and it appears CMC will sit at least one more week.

Over/Under

It's all about the UNDER 45.5 (-105) in this battle in Charlotte. The Panthers have allowed just 251.5 total yards per game, to rank third in the NFL, and they're also third with just 16.5 points per game allowed.

They're hard on the run, too, allowing just 95.0 rushing yards per game, so QB Jalen Hurts might have a tough time getting going. Expect defense to reign supreme.

Week 5 best bets

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