First look: Cleveland Browns at Los Angeles Chargers odds and lines

Ken Pomponio

Sportsbook Wire

The Cleveland Browns (3-1) are riding a three-game win streak as they head west in Week 5 to visit the Los Angeles Chargers (3-1). Kickoff is set for 4:05 p.m. ET Sunday at SoFi Stadium. Below, we look at the Browns vs. Chargers odds and lines; check back for our NFL picks and predictions.

Since their opening-week loss at the Kansas City Chiefs, the Browns have reeled off wins over the Houston Texans (31-21), Chicago Bears (26-6) and Minnesota Vikings (14-7).

Cleveland has done so on the backs of the league's top-ranked rushing attack (177.0 yards per game) - featuring RBs Nick Chubb (362 yards, 3 TD) and Kareem Hunt (234, 3 TD) - and a DE Myles Garrett-led defense which ranks in the top four in points (16.8) and yards (250.3) allowed per game and total sacks (14).

The Chargers, meanwhile, have notched two straight impressive AFC West victories, winning 30-24 on the road at Kansas City and knocking off the previously unbeaten Las Vegas Raiders 28-14 Monday. QB Justin Herbert (9 TD, 3 INT) and running back Austin Ekeler (424 yards from scrimmage, 4 total TD) lead a potent offense while the Bolts rank seventh with 18.5 points allowed per contest.

Also see:All Week 5 odds and lines

Browns at Chargers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Tuesday at 8:51 a.m. ET.

Money line: Browns -110 (bet $110 to win $100) | Chargers -110 (bet $110 to win $100)
Against the spread (ATS): Browns +0.5, -110, (bet $110 to win $100) | Chargers -0.5, -110 (bet $110 to win $100)
Over/Under (O/U): 49.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

Also see:Betting 101

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2021 betting stats:

ML : Browns 3-1 | Chargers 3-1
ATS : Browns 3-1 | Chargers 3-1
O/U : Browns 2-2 | Chargers 0-4

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Browns vs. Chargers head-to-head

Los Angeles holds a 17-9-1 lead in the all-time series, including an 8-4 record serving as a host in California.

The Chargers won seven of nine meetings straight up (3-6 ATS) since 2003 and rolled to a 38-14 win in 2018 when they last met, easily covering as one-point road underdogs.

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