First look: Tennessee Titans at Jacksonville Jaguars odds and lines

Andrew Reid

Sportsbook Wire

The Tennessee Titans (2-2) and the AFC South rival Jacksonville Jaguars (0-4) have a Week 5 meeting Sunday at TIAA Bank Field. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Titans vs. Jaguars odds and lines; check back for our NFL picks and predictions.

Alsosee:All Week 5 odds and lines

The Titans suffered a 27-24 road defeat in overtime to the New York Jets in Week 4. Tennessee was without WRs Julio Jones and A.J. Brown due to hamstring injuries, which left RB Jeremy McNichols to lead the team with 74 receiving yards on 8 receptions from 12 targets. Both wide receivers are likely to be questionable heading into the Week 5 matchup.

RB Derrick Henry compiled 157 rushing yards and a touchdown on 33 carries. However, the offensive line was unable to keep QB Ryan Tannehill upright as he was sacked 7 times for 45 yards.

The Jaguars suffered a road loss, 24-21, to the Cincinnati Bengals on Thursday Night Football in Week 4. Jacksonville led 14-0 after the first half but was unable to find its footing in the second half and scored just one touchdown over the final 30 minutes.

First overall draft pick QB Trevor Lawrence was held to just 204 yards with 0 passing touchdowns or interceptions on 17-for-24 passing. Lawrence has suffered as many losses through four weeks of an NFL career as he did through the entirety of high school and college combined.

Jacksonville lost starting WR D.J. Chark to a broken left ankle on the fourth play of the game. WR Laviska Shenault paced the team with 7 targets for 99 yards on 6 receptions, while RB James Robinson added 78 yards and 2 touchdowns on 18 carries.

Titans at Jaguars odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Monday at 1:21 p.m. ET.

Money line: Titans -205 (bet $205 to win $100) | Jaguars +165 (bet $100 to win $165)
Against the spread (ATS): Titans -3.5, -115 (bet $115 to win $100) | Jaguars +3.5, -105 (bet $105 to win $100)
Over/Under (O/U): 48.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

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2021 betting stats:

ML : Titans 2-2 | Jaguars 0-4
ATS : Titans 2-2 | Jaguars 1-3
O/U : Titans 2-2 | Jaguars 1-3

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Titans at Jaguars head-to-head

The AFC South division rivals have met 53 times dating back to 1995 when Tennessee's franchise was located in Houston. The Titans lead the all-time series 32-21.

Tennessee has won the last three meetings, and seven of the last eight, straight up. Jacksonville's lone victory since 2016 was a 20-7 home win in 2019. The Titans are 6-2 ATS in the last eight meetings.

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