The New York Giants will take on the New Orleans Saints at 1 p.m. ET on Sunday at Caesars Superdome. New Orleans is 2-1, while the Giants are 0-3. The Saints beat the Patriots last week, 28-13. The Giants lost to the Falcons, 17-14. 

Saints head coach Sean Payton has won five of six games vs. the Giants. New Orleans is favored by seven points in the latest Saints vs. Giants odds from Caesars Sportsbook, and the over-under is set at 42. Before entering any Giants vs. Saints picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 4 of the 2021 season on an incredible 123-81 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Saints vs. Giants. You can head to SportsLine to see its picks. Here are several NFL betting lines for Giants vs. Saints:

  • Saints vs. Giants spread: Saints -7
  • Saints vs. Giants over-under: 42 points

What you need to know about the Saints

Alvin Kamara totaled 118 scrimmage yards (89 rushing) and had a TD catch last week. He has 12 TDs (nine rushing) in his last six games when the Saints have been the home team. Kamara has rushed for 177 yards this season. He is the Saints' leading receiver with 10 catches, for 62 yards. 

The Saints have six interceptions, which leads the NFL. Malcolm Jenkins returned an interception 34 yards for a score in Week 3, his eighth career defensive TD. Marshon Lattimore has 10 tackles and an interception. 

What you need to know about the Giants

The Giants lost to the Falcons last week, as Atlanta hit a 40-yard field goal as time expired. It was New York's second consecutive defeat on a final play. Daniel Jones leads the Giants in rushing with 161 yards and two TDs. Saquon Barkley has rushed for 134 yards and one TD. 

Kenny Golladay had four catches for 64 yards vs. Atlanta. Collin Johnson finished with a career-best five receptions. Sterling Shepard and Darius Slayton are both out with hamstring injuries this week. 

How to make Giants vs. Saints picks

The model has simulated Saints vs. Giants 10,000 times and the results are in. The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Saints vs. Giants? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.