Dillon Dube and Connor Mackey scored for the Flames on the Left Coast.
With the loss, the Flames fell to 0-2 this preseason after losing 4-0 to the Oilers Sunday night at the Scotiabank Saddledome.
In a reversal of Sunday night, Adam Werner started for the Flames and made 12 saves on 15 shots before being replaced by Dan Vladar for the back half of the contest. He stopped 12 of 13 shots.
Michael DiPietro played the full 60 minutes for the Canucks, stopping 24 shots.
The Flames were penalized seven times Sunday night in that loss to the Oilers and found themselves on the PK early in the contest.
The Canucks made good on the advantage when Conor Garland beat Werner five-hole just 2:38 into the game.
The assist went to former fellow Coyote Oliver Ekman-Larsson.
Then it was Chase Wouters who made it 2-0 for the Canucks at 12:19.
The vistors came close to solving DiPietro when Dube - who was centering a line with Andrew Mangiapane and Brett Ritchie to start the tilt - feathered a pass through to Oliver Kylington as he snuck in from the point, but the Canucks 'tender made the stop, leading to a melee in front of the cage as Mangiapane tried to get position to knock the rebound into the net.
Mangiapane was sent off for cross-checking at the 15:18 mark and the Canucks made them pay just 15 seconds into the man-up.
Werner made the first stop on a re-direction attempt by Alex Chiasson and then after a mad scramble in front of the net, J.T. Miller poked the puck home.
The Flames got their first powerplay of the game late in the opening frame - with 1:19 left to play - when former Hitmen defenceman Jett Woo was whistled for interference on Walker Duehr.
They weren't able to score on the PP that finished off early in the second period, but they did generate some solid chances in the middle stanza.
First, it was Dube skating hard down the left wing, but DiPietro coming up big by kicking out his right pad to stop his offering.
Later it was Adam Ruzicka on a 2-on-1 with Matthew Phillips, but his pass across to the streaking Phillips going off the toe of his stick in tight to the net.
Then it was Mangiapane trying to get a breakaway, but big Canucks defenceman Tyler Myers - who played his minor hockey with the Bow Valley Flames in Calgary - was able to use his size to keep No. 88 from getting a handle on the puck and find any room.
The Flames finally cracked their preseason goose egg on a 5-on-3 powerplay, Dube taking the puck from Nick DeSimone down low and then skating up into the high slot and snapping a puck that beat DiPietro blocker side at 12:48 of the second.
Kylington got the other helper.
