It was almost a completely different team sheet from the one at the weekend after both managers made wholesale changes for this midweek cup tie.
There were 21 fresh names on duty in the starting line-ups from our 2-1 away win, with only West Ham’s Jarrod Bowen making the XIs four days on.
The Hammers took a ninth-minute lead with a goal from Manuel Lanzini and ultimately survived United's repeated attempts to equalise, on a tense and unfortunately disappointing night at Old Trafford that did not go our way.
United's focus will now return to the Premier League following an encouraging start to the top-flight campaign - joint top of the table with 13 points from 15 - with Aston Villa set to visit Old Trafford for a 12:30 BST kick-off this Saturday.