Team news and how to follow England Women vs North Macedonia Women in World Cup 2023 qualifying on Friday; kick-off 7pm.
The game marks new boss Sarina Wiegman's first in charge of the Lionesses after leading Netherlands Women during the delayed Tokyo 2020 Olympic Games this summer, as well as the beginning of a new cycle as the route to World Cup 2023 in New Zealand and Australia gets under way.
Friday's match at St Mary's is England's first official competitive international in 802 days, providing its own difficulties for Wiegman even before naming her debut squad without the capability of seeing many of her new charges play.
She told Sky Sports ahead of the game: "Most players came out of the Olympics and had a break, so we didn't see many games. The WSL started last weekend so we did get to see them and did a great job, because they had all the players ready for us and could see some footage.
"We haven't seen that much yet, I know England have very many talented players but I wanted to expand it up to 25 players, because with Covid it's difficult to get players in if you have an injury, and we get to see how players relate to each other in the group."
Captain Steph Houghton was forced to withdraw from the squad on Friday with an ankle injury sustained during the team's final training session and has returned to Manchester City for further assessment.
Arsenal's Leah Williamson will captain the side in Houghton's absence.
"First and foremost we would like to wish Steph a speedy recovery and hope to see her back fit soon," Wiegman said.
"This is also an exciting opportunity for Leah to wear the captain's armband at senior level for the first time and I look forward to seeing her in action.
"We hope to see as many of our fans as possible at this evening's match as we get our World Cup campaign under way."
England Women squad
Goalkeepers: Mary Earps (Manchester United), Sandy MacIver (Everton), Carly Telford (Chelsea)
Defenders: Millie Bright (Chelsea), Niamh Charles (Chelsea), Rachel Daly (Houston Dash), Jessica Carter (Chelsea), Alex Greenwood (Manchester City), Demi Stokes (Manchester City), Lotte Wubben-Moy (Arsenal)
Midfielders: Jill Scott (Manchester City), Lucy Staniforth (Manchester United), Georgia Stanway (Manchester City), Leah Williamson (Arsenal), Katie Zelem (Manchester United)
Forwards: Bethany England (Chelsea), Lauren Hemp (Manchester City), Fran Kirby (Chelsea), Beth Mead (Arsenal), Nikita Parris (Arsenal), Ebony Salmon (Racing Louisville), Ella Toone (Manchester United), Ellen White (Manchester City)
How to follow
Follow England Women vs Macedonia Women via the Sky Sports app and digital platforms with our live match blog providing build-up and coverage from 5.30pm; kick-off at 7pm.
- Download the Sky Sports Scores App: Apple | Android
- The UK's No 1 scores app: Find out more
England Women's World Cup 2023 qualifying campaign
September 17: England Women vs North Macedonia Women
September 21: Luxembourg Women vs England Women
October 23: England Women vs Northern Ireland Women
October 26: Latvia Women vs England Women
November 27: England Women vs Austria Women
November 30: England Women vs Latvia Women
April 8, 2022: North Macedonia Women vs England Women
April 12: Northern Ireland Women vs England Women