Leap Therapeutics Stock Is Moving Higher On Updated DKN-01 Combo Trial Data In Gastric Cancer - BeiGene (NASDAQ:BGNE), Leap Therapeutics (NASDAQ:LPTX)

Leap Therapeutics Inc LPTX announced updated data from the first-line cohort of the DisTinGuish Phase 2a trial evaluating DKN-01 combined with BeiGene Ltd’s BGNE tislelizumab and chemotherapy in gastric or gastroesophageal junction cancer (G/GEJ).
The data were presented at the European Society for Medical Oncology (ESMO21) Congress. Earlier this week, the Company announced initial data from the DisTinGuish study based on 25 G/GEJ patients.
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The results presented today included additional patient data stratified by tumoral PD-L1 expression levels.
The response was independent of PD-L1 expression and particularly strong in the less favorable to checkpoint inhibitor therapy, PD-L1 low population.
Among those patients with PD-L1-low expression, the ORR was 79%, with 100% in DKK1-high patients and 57% in DKK1-low patients.
Among those patients with PD-L1-high expression, the ORR was 67%, with 75% ORR in DKK1-high patients and 50% in DKK1-low patients.
The median duration of response and progression-free survival data are not yet mature, and patient follow-up continues.
Of the 25 patients, 15 patients had experienced a partial response (PR), six patients had the best response of stable disease (SD), one patient was non-evaluable for response (NE), and three patients were unable to complete a full cycle of DKN-01 therapy.
Price Action: LPTX shares are up 30.60% at $2.52 during the premarket session on the last check Thursday.
Check out our coverage of the European Society for Medical Oncology Congress (ESMO21)

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