AC Milan forward Zlatan Ibrahimovic will miss Wednesday's opening Champions League group match at Liverpool with an Achilles tendon problem.
"After the match he had some inflammation," said the Italian team's coach Stefano Pioli.
"We hoped he could play but he still had pain so we don't want to risk [playing him]."
Seven-time European champions Milan are making their first appearance in the Champions League since 2014 and head to Anfield with a 100% record in the Italian top flight after winning their first three fixtures this season.
Prior to the news that the Sweden forward would not be travelling to Merseyside, Liverpool manager Jurgen Klopp had praised his enduring quality.