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NFL picks, predictions for Week 2: 49ers run over Eagles; Bengals, Colts, Giants keep upsets coming

Sporting News
 2021-09-14

Cover picture for the articleIt's only Week 2, but there are just three games between unbeaten teams on the NFL schedule. Two of those games are in the NFC. The San Francisco 49ers travel to Philadelphia in what could be one of the more-entertaining games of the day. The 49ers are a road favorite worth watching. New Orleans travels to Carolina for a matchup between NFC rivals. Will Jameis Winston build on an impressive Week 1 performance?

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