Scientists Say Boosters Aren’t Needed for General Population

The New York Times
The New York Times
Raquel Gonzales, 27, receives a coronavirus vaccine during a free vaccination clinic in San Antonio, Texas on Saturday Sept. 11, 2021. (Matthew Busch/The New York Times)

None of the data on coronavirus vaccines so far provides credible evidence in support of boosters for the general population, according to a review published Monday by an international group of scientists, including some at the Food and Drug Administration and the World Health Organization.

The 18 authors include Dr. Philip Krause and Marion Gruber, FDA scientists who announced last month that they will be leaving the agency, at least in part because they disagreed with the Biden administration’s push for boosters before federal scientists could review the evidence and make recommendations.

The administration has proposed administering vaccine boosters eight months after the initial shots. But many scientists have opposed the plan, saying the vaccines continue to be powerfully protective against severe illness and hospitalization. A committee of advisers to the FDA is scheduled to meet Friday to review the data.

In the new review, published in The Lancet, experts said that whatever advantage boosters provide would not outweigh the benefit of using those doses to protect the billions of people who remain unvaccinated worldwide. Boosters may be useful in some people with weak immune systems, they said, but are not yet needed for the general population.

Several studies published by the Centers for Disease Control and Prevention, including three Friday, suggest that while efficacy against infection with the delta variant seems to wane slightly over time, the vaccines hold steady against severe illness in all age groups. Only in people older than 75 do the vaccines show some weakening in protection against hospitalization.

Immunity conferred by vaccines relies on protection both from antibodies and from immune cells. Although the levels of antibodies may wane over time — and raise the risk of infection — the body’s memory of the virus is long-lived.

The vaccines are slightly less effective against infection with the delta variant than with the alpha variant, but the virus has not yet evolved to evade the sustained responses from immune cells, the experts said. Boosters may eventually be needed even for the general population if a variant emerges that sidesteps the immune response.

The experts cautioned that promoting boosters before they are needed, as well as any reports of side effects from booster shots such as heart problems or Guillain-Barre syndrome, may undermine confidence in the primary vaccination.

Data from Israel suggest that booster doses enhance protection against infection. But that evidence was collected just a week or so after the third dose and may not hold up over time, the experts said.

This article originally appeared in The New York Times .

Comments / 2243

Silvia Torres

The vaccine is not for everyone. I almost lost my sister. She became deathly ill after I convinced her to get it. When I rushed her to the hospital and saw the staff hook her up to iv' and oxygen mask I began to pray for God to spare her and forgive me. It was a long painful process to recovery. She was told NOT to get the second vaccine by the doctor. I pray no one has to deal with the guilt I experienced. Let us respect and acknowledge that we are all different. Stop pushing your own agenda on everyone. No one knows how it will affect the other.

Audrey Kaye Allen

I just want to know when they going to start vaccinating the people coming across our National boarders unvaccinated? Instead of loading them on planes and buses and sending all over the United States, but requiring them for the US citizens.

Melissa Yackley

That’s because we have a shortage. Once we have enough they will be whistling a new tune. Remember when Fauci told us we didn’t need masks, now masks are all anyone can think of


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