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Common arthritis drug may help reduce COVID-19 death

Knowridge Science Report
Knowridge Science Report
 2021-09-05
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In a new study from Vanderbilt University, researchers found hospitalized patients with COVID-19 who received the rheumatoid arthritis drug baricitinib, in combination with the standard of care including corticosteroids, died less often than those receiving only the standard of care.

Hospitalized patients with the SARS-CoV-2 infection (which causes COVID-19), often develop an intense hyperinflammatory state that can lead to dysfunction of multiple organs, including acute respiratory distress syndrome, septic shock and death.

Despite treatment advances with remdesivir, dexamethasone and tocilizumab, reducing mortality among hospitalized patients remains a crucial unmet need.

The study included 1,525 hospitalized patients on supplemental oxygen from 101 centers across 12 countries in Asia, Europe, North America and South America.

Patients were assigned to receive baricitinib vs. placebo once a day for up to 14 days in addition to the standard of care, which included the medications dexamethasone and remdesivir.

The team discovered that baricitinib reduces 28-day and 60-day mortality by 5% as compared to placebo.

The team says it is increasingly evident that treatment with baricitinib may help prevent death in some of the most critically ill COVID-19 patients.

This class of medications represents an important treatment advance for this vulnerable group of patients in the constantly evolving pandemic,” Ely said.

Baricitinib is an inhibitor of Janus kinases (JAK) 1 and 2, which calms down the immune system.

Huge computer analysis was done early in the pandemic, trying to figure out what drugs were the best to repurpose for COVID anti-viral effects. Anti-inflammatory effects are also important for sicker, hospitalized patients.

JAK inhibitors selectively hit signaling via the JAK receptors, blocking transduction pathways that lead to inflammation.

Drugs like baricitinib stop multiple pathways of the inflammatory cascade to hold down the inflammation that COVID would usually start.

The team says that the sicker patients were at the time of enrollment, the greater the reduction in mortality.

One surprising finding is that although the drug reduces death, some patients still progress in their severity of illness.

Baricitinib was identified in February 2020 as a potential intervention for the treatment of COVID-19.

The FDA granted Emergency Use Authorization (EUA) to the drug in November 2020, to be given in combination with the drug remdesivir, then amended the EUA later to allow baricitinib to be given with or without remdesivir.

If you care about COVID, please read studies about this common heartburn drug may help treat COVID-19, reduce severity and findings of existing drugs that can kill COVID-19 virus.

For more information about COVID and your health, please see recent studies about vitamin D and COVID-19: What you need to know and results showing that these old vaccines can fight COVID-19 pandemic.

The study is published in The Lancet Respiratory Medicine. One author of the study is E. Wesley Ely, MD, MPH.

Copyright © 2021 Knowridge Science Report. All rights reserved.

Comments / 37

CubanAmerican Patriot
09-07

Almost from the beginning of this pandemic, REAL doctors were SUCCESSFULLY treating patients with proven therapeutics such as HCQ, Ivermectin, Budesonide, etc. REAL doctors were recommending vitamins and minerals to prevent disease. REAL doctors were telling us PCR tests were NOT valid. Why do you think the media told everyone none of this worked? Think about it. It was because the media and politicians were bought by the pharma companies. And in order to get Emergency Use Authorization for their highly profitable experimental drugs (“vaccines”) they needed to tell the world that no therapeutics existed (even though they did). So, doctors who were also misled and lied to, told infected patients to stay home and “tough it out,” which resulted hundreds of thousands of hospitalizations and horrible deaths.

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Carolyn Bartley
09-07

this crappy covid been here for way over a year. they came out with a vaccine in just 9 months that ain't working. you can plainly see it isn't! But they can't get enough data on Hydroxychloroquine or Ivermectine which people have taken both for over 40 years. People are dying. This administration clearly doesn't know how to fix this problem of Covid. Vote them out and put new Reps in !

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Tony Esker
09-05

hydrycloroquine is a well known arthritis drug also

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