Santana (2-4) allowed one earned run on four hits while striking out one across 1.1 innings, taking the loss to the Angels on Friday.
Santana allowed three hits in the sixth inning to allow the Angels to take the lead. It was his second relief loss in his last four appearances. The 25-year-old has a 5.44 ERA and 1.65 WHIP with 35 strikeouts in 43 innings this season.