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New therapeutic method combined with synthetic CDK4/6 inhibitors for refractory cancers

MedicalXpress
 2021-09-02

Cover picture for the articleThe RB1 tumor suppressor gene protein antagonizes uncontrolled growth of cancer by suppressing cell cycle progression but its function is repressed in most cancers. CDK4/6 represses this function by phosphorylating RB1. In contrast, drugs that inhibit CDK4/6 inhibit the phosphorylation of RB1 and restore the cancer-suppressing function of RB1. However, since...

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