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Triplet Combination Demonstrates Promise for Frontline Treatment of BRAF V600E–mutant CRC

onclive.com
 2021-07-28

Doublet and triplet chemotherapy-based therapies are standard treatment options for patients with BRAF V600–mutant metastatic colorectal cancer. Doublet and triplet chemotherapy-based therapies are standard treatment options for patients with BRAF V600–mutant metastatic colorectal cancer (CRC). However, this population of patients have traditionally poor outcomes with chemotherapy-based regimens, yet BRAF inhibitors alone are not effective enough to overcome the feedback activation of EGFR.1.

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